| Project/Area Number |
25670607
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
CHEN Fengshi 京都大学, 医学(系)研究科(研究院), 講師 (00452334)
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| Co-Investigator(Kenkyū-buntansha) |
伊達 洋至 京都大学, 医学研究科, 教授 (60252962)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 抗体関連拒絶 / 肺移植 / 生体肺移植 / ドナー特異的抗体 / HLA抗体 / 免疫抑制 |
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| Outline of Final Research Achievements |
Because of the severe shortage of brain-dead donors, living-donor lung transplantation has been significantly performed in Japan; however, it has been hampered due to the blood type incompatibility and the existence of donor specific antibodies (DSA). Therefore, it is important to conduct an investigation aiming for lung transplantation with ABO-incompatible and DSA positive donors. Recently, attentions have been paid to postoperative de novo DSA and antibody-mediated rejection worldwide, but few consensus statements have been documented in the field of lung transplantation. In this situation, this study investigated the incidence of de novo DSA production and antibody-mediated rejection, and their treatments from the multiple aspects. This study found that there were significant differences between living-donor and cadaveric lung transplantations in terms of the incidence of de novo DSA production, its timing, its duration, and its type of HLA classes.
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