| Project/Area Number |
25670611
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory surgery
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| Research Institution | Miyagi Prefectural Hospital Organization Miyagi Cancer Center |
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Principal Investigator |
ABE Jiro 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), その他部局等, 特任研究員 (10573686)
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| Co-Investigator(Kenkyū-buntansha) |
SATOH Kennichi 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 部長 (10282055)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 肺癌 / 人工がん幹細胞 / HOTAIR / 癌幹細胞 |
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| Outline of Final Research Achievements |
In order to develop the new therapeutic strategy for non-small cell lung cancer (NSCLC) stem cell, we tried to establish artificial cancer stem cell line. As cancer stem cell related molecule, we focused on large non-coding RNA HOTAIR. Lung cancer cells (A549) showed increased cellular migration in HOTAIR dependent munner. In addition, the expression of HOTAIR was found especially in aggressive NSCLC and was significantly correlated with shorter disease free survival, suggesting that HOTAIR might be involved in the property of cancer stem cell of NSCLC.
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