Development of pediatric MEG measurement without sedation

• Project/Area Number: 25670614
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Tohoku University
• Principal Investigator: NAKASATO Nobukazu 東北大学, 医学(系)研究科(研究院), 教授 (80207753)
• Co-Investigator(Kenkyū-buntansha): 岩崎 真樹 東北大学, 大学病院, 講師 (00420018) ; 神 一敬 東北大学, 医学(系)研究科(研究院), 講師 (20436091) ; 菅野 彰剛 東北大学, 加齢医学研究所, 助教 (20578968) ; 柿坂 庸介 東北大学, 大学病院, 助教 (90400324)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 脳磁図 / てんかん / 脳機能マッピング / 良性部分てんかん / 帯状回てんかん / 聴覚定常応答 / 脳溝底部 / 皮質形成異常

Outline of Final Research Achievements

We applied superconducting quantum interference device (SQUID)-based magnetoencephalography (MEG) to measure both normal brain function and epilepsy-related abnormal activity for future development of tunnel-magnetic-registance (TMR)-based high resolution MEG system. Subjects were people with epilepsy with focal cortical dysplasia, with various types of age-dependent epilepsy, or with interhemispheric foci; and normal subjects. Time-axis waveformes and sensor-based isofield maps were analyzed for both epileptic and normal auditory function. These basic data can be used to apply future development of high-resolution MEG system using TMR sensors.

Research Products

• [Journal Article] Obsessive-compulsive behavior induced by levetiracetam. (2015)
  • Author(s): Fujikawa M, Kishimoto Y, Kakisaka Y, Jin K, Kato K, Iwasaki M, Nakasato N
  • Journal Title: J Child Neurol Volume: in press Issue: 7 Pages: 942-944
  • DOI: 10.1177/0883073814541471
  • Peer Reviewed
• [Journal Article] 不快な感覚・尿意切迫感を自覚する単純部分発作を呈した前帯状回てんかんの一例. (2015)
  • Author(s): 吉野彰兼、柿坂庸介、神一敬, 加藤量広, 佐藤志帆、藤川真由、北澤悠、岩崎真樹、板橋尚、中里信和.
  • Journal Title: 小児科臨床 Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Effects of contralateral noise on the 20-Hz auditory steady state response - magnetoencephalography study. (2014)
  • Author(s): Usubuchi H, Kawase T, Kanno A, Yahata I, Miyazaki H, Nakasato N, Kawashima R, Katori Y
  • Journal Title: PLoS ONE Volume: 9 Issue: 6 Pages: e99457-e99457
  • DOI: 10.1371/journal.pone.0099457
  • Peer Reviewed / Open Access
• [Journal Article] Earlier tachycardia onset in right than left mesial temporal lobe seizures. (2014)
  • Author(s): Kato K, Jin K, Itabashi H, Iwasaki M, Kakisaka Y, Aoki M, Nakasato N
  • Journal Title: Neurology Volume: 83 Issue: 15 Pages: 1332-1336
  • DOI: 10.1212/wnl.0000000000000864
  • Peer Reviewed
• [Journal Article] 両側頭蓋内電極留置によって術前精査と逆側の発作起始を捉えた側頭葉てんかんの１手術例. (2014)
  • Author(s): 岩崎真樹，神一敬，加藤量広，大沢伸一郎，下田由輝，中里信和，冨永悌二
  • Journal Title: 脳外誌 Volume: 23 Pages: 744-749
  • NAID: 130004692085
  • Peer Reviewed
• [Journal Article] 複数の発作周辺期精神症状を含む多彩な発作症状を呈した部分てんかんの１例 (2014)
  • Author(s): 江面道典，柿坂庸介，神一敬，加藤量広，岩崎真樹，藤川真由，青木正志，中里信和
  • Journal Title: BRAIN and NERVE Volume: 67 Pages: 105-109
  • Peer Reviewed
• [Journal Article] Brain electrical source analysis (BESA) epilepsy を使用した長時間脳波判読補助：新人脳波技師と脳波認定医の比較～小人数での予備的検討～． (2014)
  • Author(s): 板橋泉，岩崎真樹，神一敬，櫻庭理絵，加藤量広，板橋尚，中里信和
  • Journal Title: 臨床神経生理学 Volume: 42 Pages: 100-105
  • Peer Reviewed
• [Journal Article] Brain Electrical Source Analysis (BESA) Epilepsy を使用した長時間脳波判読補助：棘波検出の効率化の検討． (2014)
  • Author(s): 櫻庭理絵，岩崎真樹，神一敬，板橋泉，加藤量広，板橋尚，中里信和
  • Journal Title: 臨床神経生理学 Volume: 42 Pages: 78-83
  • NAID: 130005078725
  • Peer Reviewed
• [Journal Article] Electro- and magneto-encephalographic spike source localization in patients with small focal cortical dysplasia in the dorsal peri-rolandic region (2014)
  • Author(s): Itabashi H, Jin K, Iwasaki M, Okumura E, Kanno A, Kato K, Tominaga T, Kawashima R, Nakasato N
  • Journal Title: Clin Neurophysiol Volume: in press
  • Peer Reviewed
• [Journal Article] Positive auditory cortical responses in patients with absent brainstem response (2014)
  • Author(s): Kawase T, Kanno A, Tanaka Y, Nakasato N, Kawashima R, Kobayashi T
  • Journal Title: Clin Neurophysiol Volume: in press
  • Peer Reviewed
• [Journal Article] Time-varying inter-hemispheric coherence during corpus callosotomy (2014)
  • Author(s): Okumura E, Iwasaki M, Sakuraba R, Itabashi I, Osawa SI, Jin K, Itabashi H, Kato K, Kanno A, Tominaga T, Nakasato N
  • Journal Title: Clin Neurophysiol Volume: in press
  • Peer Reviewed
• [Journal Article] Magnetoencephalography localizing spike sources of atypical benign partial epilepsy (2014)
  • Author(s): Shiraishi H, Haginoya K, Nakagawa E, Saitoh S, Kaneko Y, Nakasato N, Chan D, Otsubo H
  • Journal Title: Brain Dev Volume: in press
  • Peer Reviewed
• [Journal Article] Optogenetically induced seizure and the longitudinal hippocampal network dynamics (2013)
  • Author(s): Osawa S, Iwasaki M, Hosaka R, Matsuzaka Y, Tomita H, Ishizuka T, Sugano E, Okumura E, Yawo H, Nakasato N, Tominaga T, Mushiake H
  • Journal Title: PLoS One Volume: 10;8(4)
  • NAID: 120005435470
  • Peer Reviewed
• [Journal Article] 脳磁図を用いたてんかん診断の臨床応用：最近の動向と将来展望 (2013)
  • Author(s): 平田雅之，亀山茂樹，柳澤琢史，貴島晴彦，押野 悟，吉峰俊樹，井口義信，石井良平， 尾崎勇， 鎌田恭輔，白石秀明，露口尚弘，渡辺裕貴，中里信和，橋本勲
  • Journal Title: 日本生体磁気学会誌 Volume: 26 Pages: 138-139
  • Peer Reviewed
• [Journal Article] 脳磁図の臨床応用：虚血性脳血管障害領域での最近の動向と将来展望 (2013)
  • Author(s): 露口尚弘，鎌田恭輔，中里信和，宇田武弘，池田英敏，坂本真一，尾崎勇，井口義信，平田雅之，亀山茂樹，石井良平，白石秀明，渡辺裕貴，中里信和，橋本勲
  • Journal Title: 日本生体磁気学会誌 Volume: 26 Pages: 140-141
  • Peer Reviewed
• [Journal Article] 脳磁図を用いた小児疾患診断の臨床応用：最近の動向と将来展望 (2013)
  • Author(s): 白石秀明，尾崎勇，井口義信，石井良平，鎌田恭輔，亀山茂樹，露口尚弘，中里信和, 平田雅之，渡辺裕貴，橋本勲
  • Journal Title: 日本生体磁気学会誌 Volume: 26 Pages: 142-143
  • Peer Reviewed
• [Journal Article] 脳磁図の臨床応用：精神科疾患・認知症領域での最近の動向と将来展望 (2013)
  • Author(s): 石井良平，渡辺裕貴，青木保典，平田雅之，白石秀明，尾崎勇，井口義信，露口尚弘，鎌田恭輔，亀山茂樹，中里信和，橋本勲，武田雅俊
  • Journal Title: 日本生体磁気学会誌 Volume: 26 Pages: 144-145
  • Peer Reviewed
• [Journal Article] ビデオ脳波モニタリングおよび脳磁図を用いた外傷性てんかんの診断 (2013)
  • Author(s): 板橋泉，神一敬，岩崎真樹，加藤量広，板橋尚，菅野彰剛，冨永悌二，川島隆太，中里信和
  • Journal Title: 日本生体磁気学会誌 Volume: 26 Pages: 192-193
  • Peer Reviewed
• [Presentation] Detection and localization of EEG and MEG spikes in cases with small cortical dysplasia often overlooked on MRI (2014)
  • Author(s): Nakasato N, Itabashi H, Jin K, Iwasaki M, Tominaga T
  • Organizer: 8th Asian Epilepsy Surgery Congress
  • Place of Presentation: Toshi Center Hotel (Tokyo), Japan
  • Year and Date: 2014-10-06
  • Invited
• [Presentation] Epilepsy: Theory and Grounding (2014)
  • Author(s): Nakasato N, Rampp S
  • Organizer: 19th International Conference on Biomagnetism
  • Place of Presentation: Halifax, Canada
  • Year and Date: 2014-08-25
  • Invited
• [Presentation] 脳磁図の“眼”でみるてんかんの病態生理 (2014)
  • Author(s): 柿坂庸介、岩崎真樹、神一敬、加藤量広、藤川真由、中里信和
  • Organizer: 第29回日本生体磁気学会
  • Place of Presentation: 大阪大学吹田キャンパスコンベンションセンター（吹田市）
  • Year and Date: 2014-05-29 – 2014-05-30
  • Invited
• [Presentation] 交通外傷後遷延性意識障害患者における体性感覚誘発磁界高周波振動 (2014)
  • Author(s): 菅野彰剛，中里信和，長嶺義秀，川島隆太
  • Organizer: 第29回日本生体磁気学会
  • Place of Presentation: 大阪大学吹田キャンパスコンベンションセンター（吹田市）
  • Year and Date: 2014-05-29 – 2014-05-30
• [Presentation] Functional imaging for epilepsy surgery (2013)
  • Author(s): Nakasato N
  • Organizer: The World Society for Stereotactic and Functional Neurosurgery
  • Place of Presentation: Tokyo
  • Invited
• [Presentation] MEG and EEG spike localization in cases with small FCD overlooked by MRI (2013)
  • Author(s): Nakasato N
  • Organizer: Colloquium on Drug Resistant Epilepsy
  • Place of Presentation: NIMHANS, Bangalore, India
  • Invited