| Project/Area Number |
25670616
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
MORITAKE Takashi 産業医科大学, 産業生態科学研究所, 准教授 (50450432)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Yoshitaka 筑波大学, 医学医療系, 助教 (70510395)
HIRAYAMA Aki 筑波技術大学, 保健科学部, 教授 (20323298)
坪井 康次 筑波大学, 医学医療系, 教授 (90188615)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | Electron Spin Resonance / Cancer Stem Cell / Cell Cycle / Radiation / 脳腫瘍額 / 癌幹細胞 / 電子スピン共鳴 / がん幹細胞 / 細胞周期 |
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| Outline of Final Research Achievements |
In 2014, we analyzed of redox balance and migration/invasion of brain tumor stem cells. Further it was tried to develop a horizontal resonance cavity for in vitro imaging by the reducing ability of the cells using the electron spin resonance (ESR). Brain tumor cells irradiated to x-ray were revealed that reducing ability was significantly enhanced; in the brain tumor stem cells, unexpectedly reducing ability was not so much enhanced. The brain tumor stem cells after irradiation were increased the invasive potential than non-stem cells. The remodeled ESR resonance cavity for imaging was confirmed to operate normally.
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