Devascularization therapy of glioma by using endothelial progenitor cells and trafficking
| Project/Area Number |
25670621
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | グリオーマ / グリア代謝 / 酢酸PET / 血管内皮前駆細胞 / 脳腫瘍 / ラット / C6グリオーマ / 酢酸 / 代謝 / PET |
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| Outline of Final Research Achievements |
Brain tumor mode was made by transplantation of 1x10 5 C6 glioma cells. Because of technical difficulty, semi-quantitative analysis of 12C-acetate autoradiography was performed on this model instead of quantitative analysis of 12C-fluoroacetate PET. This study clearly showed uncreased uptake of 12C-acetate into the tumor, which glial metabolism was increased in the glioma cells. We also intravenous administration of bone marrow-deribed endothelial progenitor cells (BM-EPCs) in this brain tumor model. However, it was doubtful BM-EPCs were gathering into the tumors.
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Report
(4 results)
Research Products
(12 results)
