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microRNA/mRNA expression profile for further elucidation of the mechanism of cerebral vasospasm and identification of novel biomarkers

Research Project

Project/Area Number 25670624
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Neurosurgery
Research InstitutionKyushu University

Principal Investigator

MIZOGUCHI Masahiro  九州大学, 大学病院, 講師 (50380621)

Co-Investigator(Kenkyū-buntansha) KIKKAWA Yuichiro  埼玉医科大学, 医学部, 講師 (80423515)
NAKAMIZO Akira  九州大学, 大学院医学研究院, 研究員 (80529800)
AMANO Toshiyuki  九州大学, 大学病院, 助教 (70448413)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords脳血管障害 / 脳血管攣縮 / くも膜下出血 / microRNA / 遺伝子発現 / early brain injury
Outline of Final Research Achievements

Cerebral vasospasm is a reversible contraction of the cerebral artery after subarachnoid hemorrhage, which is a critical complication that defines the prognosis of the patients. By miRNA/ mRNA expression analysis in the brain and cerebral vessels in animal models, we identified overexpression of MMP-9, miR-21 and underexpression of TIMP3, miR-351 and its relevance after subarachnoid hemorrhage. Also, after subarachnoid hemorrhage, Relaxin, which was highly expressed in crebral vessels, Further investigation revealed that Relaxin, which was highly expressed in crebral vessels, is also detected even in the cerebrospinal fluid and serum. The results of this study revealed that the analysis based on the miRNA / mRNA expression profiles may lead to elucidation of novel cerebral vasospasm mechanism and identification of novel biomarkers.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (7 results)

All 2015 2014 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 1 results) Presentation (4 results)

  • [Journal Article] Upregulation of tissue inhibitor of metalloproteinase-1 contributes to restoration of the extracellular matrix in the rabbit basilar artery during cerebral vasospasm after subarachnoid hemorrhage2015

    • Author(s)
      Ryota Kurogi; Yuichiro Kikkawa; Satoshi Matsuo; Akira Nakamizo; Masahiro Mizoguchi; Tomio Sasaki
    • Journal Title

      Brain Research

      Volume: *

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Gene Expression Profiling and Bioinformatic Analysis of Rabbit Basilar Artery after Experimental Subarachnoid Hemorrhage2014

    • Author(s)
      Matsuo S, Kikkawa Y, Hokama M, Kurogi R, Nakamizo A, Mizoguchi M, Sasaki T
    • Journal Title

      J Neurol Neurophysiol

      Volume: *

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mechanism underlying Increased Vascular Smooth Muscle Contractility in the Rabbit Basilar Artery following Subarachnoid Hemorrhage2014

    • Author(s)
      Kikkawa Y, Kameda K, Matsuo S, Kurogi R, Nakamizo A, Mizoguchi M, Sasaki T
    • Journal Title

      Acta Neurochir Suppl

      Volume: *

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] ラットくも膜下出血モデルにおけるMMP-9関連micro RNAの発現解析2015

    • Author(s)
      黒木亮太、佐山徹郎、溝口昌弘、中溝玲、森恩、橋口公章、天野敏之、吉川雄一郎、吉本幸司、飯原弘二
    • Organizer
      Stroke 2015、第31回スパズム・シンポジウム
    • Place of Presentation
      広島
    • Year and Date
      2015-03-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] ウサギくも膜下出血モデル脳底動脈におけるrelaxinの発現とその役割

    • Author(s)
      松尾 諭、吉川 雄一郎、黒木 亮太、 中溝 玲、吉本 幸司、 溝口 昌弘、佐々木 富男
    • Organizer
      第72回日本脳神経外科学会総会
    • Place of Presentation
      神奈川
    • Related Report
      2013 Research-status Report
  • [Presentation] ウサギくも膜下出血モデル脳底動脈における細胞外マトリックスのリモデリングに関わるタンパク質の発現変動とその役割

    • Author(s)
      黒木 亮太、吉川 雄一郎、松尾 諭、中溝 玲、吉本 幸司、溝口 昌弘、佐々木 富男
    • Organizer
      第72回日本脳神経外科学会総会
    • Place of Presentation
      神奈川
    • Related Report
      2013 Research-status Report
  • [Presentation] ultra-high resolution CTを用いた 脳血管攣縮と微小脳循環評価の試み

    • Author(s)
      吉川雄一郎、松尾 諭、黒木亮太、 中溝 玲、溝口昌弘、飯原弘二、佐々木富男
    • Organizer
      第30回スパズムシンポジウム
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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