| Project/Area Number |
25670624
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KIKKAWA Yuichiro 埼玉医科大学, 医学部, 講師 (80423515)
NAKAMIZO Akira 九州大学, 大学院医学研究院, 研究員 (80529800)
AMANO Toshiyuki 九州大学, 大学病院, 助教 (70448413)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 脳血管障害 / 脳血管攣縮 / くも膜下出血 / microRNA / 遺伝子発現 / early brain injury |
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| Outline of Final Research Achievements |
Cerebral vasospasm is a reversible contraction of the cerebral artery after subarachnoid hemorrhage, which is a critical complication that defines the prognosis of the patients. By miRNA/ mRNA expression analysis in the brain and cerebral vessels in animal models, we identified overexpression of MMP-9, miR-21 and underexpression of TIMP3, miR-351 and its relevance after subarachnoid hemorrhage. Also, after subarachnoid hemorrhage, Relaxin, which was highly expressed in crebral vessels, Further investigation revealed that Relaxin, which was highly expressed in crebral vessels, is also detected even in the cerebrospinal fluid and serum. The results of this study revealed that the analysis based on the miRNA / mRNA expression profiles may lead to elucidation of novel cerebral vasospasm mechanism and identification of novel biomarkers.
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