| Project/Area Number |
25670626
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Neurosurgery
|
|---|
| Research Institution | Nippon Medical School |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
|
|---|
| Keywords | 脳腫瘍 / グリオーマ / 超音波 / sonodynamic therapy / aminolevulinic acid / glioma / Fibroblast Growth Factor / glioma stem cell / sonochemical therapy / ultrasound / protoporphyrin IX |
|---|
| Outline of Final Research Achievements |
Research on Sonochemical therapy has been conducted by our group and anti-tumor effect on malignant glioma was revealed. One of the mechanisms of anti-tumor effects was elucidated. Expression of glioma stem cell markers was evaluated and no marked change was found after sonochemical therapy. While fibroblast growth factor and its receptor, were down-regulated after sonochemical therapy. Since FGF and FGFR are known as the growth activating factor, the suppression of FGF and its receptor was suggested to be one of the mechanisms.
|
