Pore design for the microporous covered stents to maintain blood flow in branching arteries after stenting

• Project/Area Number: 25670628
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: NAKAYAMA Yasuhide 独立行政法人国立循環器病研究センター, 研究所, 室長 (50250262)
• Co-Investigator(Kenkyū-buntansha): NAKAYAMA Atsuyoshi 独立行政法人産業技術総合研究所, 研究員 (10357676)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: ステント / 脳動脈瘤 / 血管内治療 / 脳動脈瘤治療 / 頭蓋内ステント / 能動脈瘤治療

Outline of Final Research Achievements

The treatment of large wide-necked cerebral aneurysms is extremely difficult. The covered stents were prepared using balloon-expandable stents by dip-coating to completely cover their struts with polyurethane film and microprocessing to form the honeycomb pattern after expansion. In an the large, wide-necked, outer-sidewall aneurysm canine model, almost all parts of the aneurysms had embolized immediately after stenting, and histological examination at 2 months revealed neointimal formation with complete endothelialization at all stented segments and entirely organized aneurysms. In a perforating artery rabbit model, the lumbar arteries remained patent, with minimal change in the vascular flow pattern, even after placement of a second, overlapping stent. Excellent embolization performance of the designed microporous covered stents without disturbing branching flow was confirmed at the aneurysms in this pilot examination.

Research Products

• [Journal Article] Treatment of rabbit carotid aneurysms by hybrid stents (microporous thin polyuretahane-covered stents): Preparation of side-barnches (2014)
  • Author(s): Nishi S, Nakayama Y, Ishibashi-Ueda H, Yoshida M, Yonetani H
  • Journal Title: J Biomat App Volume: 28 Issue: 7 Pages: 1097-1104
  • DOI: 10.1177/0885328213498293
  • Peer Reviewed
• [Journal Article] Occlusion of canine aneurysms using microporous self-expanding stent grafts: Long-term follow-up (2014)
  • Author(s): Nishi S, Nakayama Y, Ishibashi-Ueda H, Yoshida M
  • Journal Title: Clinical Neurology Neurosurgery Volume: 122 Pages: 34-41
  • DOI: 10.1016/j.clineuro.2014.04.013
  • Peer Reviewed
• [Journal Article] Occlusion of canine aneurysms using microporous self-expanding stent grafts: Long-term follow-up (2014)
  • Author(s): Nishi S, Nakayama Y, Ishibashi-Ueda H, Yoshida M, Yonetani H
  • Journal Title: Clinical Neurology Neurosurgery
  • Peer Reviewed
• [Journal Article] 脳動脈瘤治療用多孔薄膜カバードステントの開発（薄膜留置による瘤塞栓性能の評価と微細孔形状の最適化） (2013)
  • Author(s): 田地川勉, 中川雄太, 紅林芳嘉, 西正吾, 中山泰秀
  • Journal Title: 日本機械学会論文集B編 Volume: 79 Pages: 992-1004
  • NAID: 130003374834
  • Peer Reviewed
• [Presentation] Successful preclinical study of microporous covered stents for intracranial aneurysms (2014)
  • Author(s): Nakayama Y, Satow T, Hamano E, Funayama M, Mizuno T, Kawajiri H, Ishii D, Hayashi M, Tajikawa T
  • Organizer: American Heart Association Scientific Sesson 2014
  • Place of Presentation: Chicago
  • Year and Date: 2014-11-16 – 2014-11-18
• [Presentation] Establishment of experimental animal models suitable for feasibility testing in the develop,ent of covered stent for intracranial aneusysms (2014)
  • Author(s): Satow T, Nakayama Y, Hamano E, Mizuno T, Funayama M, Ishii D, Hayashi M, Moriwaki T, Kawajiro H, Nishi S
  • Organizer: ASNR 52nd Annual Meeting & The Foundation of the ASNR Symposium 2014
  • Place of Presentation: Montreal
  • Year and Date: 2014-05-17 – 2014-05-22
• [Presentation] Successful one-device-treatment of intracranial giant and/or wide neck aneurysms. 3 Essential in vivo experimental designs for pre-clinical evaluation (2014)
  • Author(s): Nakayama Y, Satow T, Hamano E, Mizuno T, Funayama M, Ishi D, Hayasgu M, Moriwaki T, Kawajiri H
  • Organizer: International Congress of the European Society for Cardiovascular and Endovascular Surgery
  • Place of Presentation: Nice
  • Year and Date: 2014-04-24 – 2014-04-27
• [Presentation] 脳動脈治療用多孔薄膜カバードステントの開発：瘤の幾何学形状が瘤塞栓性能に及ぼす影響 (2014)
  • Author(s): 森脇健司, 紅林芳嘉, 花城卓也, 田地川勉, 中山泰秀
  • Organizer: 日本機械学会第26回バイオエンジニアリング講演会
  • Place of Presentation: 仙台
• [Presentation] 内膜再生を促進する脳動脈瘤塞栓治療用カバードステントの開発：非臨床動物実験系の基準化 (2014)
  • Author(s): 中山泰秀, 佐藤 徹, 濱野栄佳, 船山麻理菜, 林 正孝, 石井大造, 水野壮司, 川尻英長, 森脇健司, 田中孝晴, 杉浦寿史
  • Organizer: 第13回日本再生医療学会
  • Place of Presentation: 京都国際会館
• [Presentation] 脳動脈瘤治療用多孔薄膜カバードステントの開発：親血管の湾曲が瘤塞栓性能の及ぼす影響 (2014)
  • Author(s): 日高涼, 森脇健司, 田地川勉, 山本恭史, 坂東潔, 中山泰秀
  • Organizer: 日本機械学会関西支部
  • Place of Presentation: 大阪
• [Presentation] In vivo performance of microporous covered stents for treating cerebral aneurysms (2013)
  • Author(s): Y. Nakayama, T. Satow, E. Hamano, T. Mizuno, M. Funayama, K. Ihara
  • Organizer: European Society for Artificial Organs Conference 2013
  • Place of Presentation: イギリス、グラスゴー
• [Presentation] 脳動脈瘤治療用カバードステントの開発 動物実験モデルの作製 (2013)
  • Author(s): 中山 泰秀, 佐藤 徹, 濱野 栄佳, 船山 麻理菜, 水野 壮司, 川尻 英長, 森脇 健司, 杉浦 寿史, 飯原 弘二
  • Organizer: 日本人工臓器学会
  • Place of Presentation: パシフィコ横浜