| Project/Area Number |
25670631
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Jichi Medical University (2014)
The University of Tokyo (2013) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KADONO Yuho 東京大学, 医学部附属病院, 講師 (70401065)
TAKETOMI Shuji 東京大学, 医学部附属病院, 助教 (70570018)
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| Research Collaborator |
OKADA Keita
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 関節軟骨 / 低酸素 / 軟骨 |
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| Outline of Final Research Achievements |
The aim of this project was to investigate the changes in oxygen concentration of articular cartilage during the progression of osteoarthritis and to elucidate the molecular mechanism underlying osteoarthritis. We found that the concentration of oxygen in the articular cartilage increases during osteoarthritis and the expression of HIF-1α decreases related to the oxygen change. HIF-1α suppression caused increase of catabolic factors such as MMP13 and MMP9 both in vitro and in vivo, suggesting the anti-catabolic effect of HIF-1α. Hence, the progression of osteoarthritis is related to the increase of oxygen concentration which decreases HIF-1α expression and causes catabolic factors to increase.
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