Clarification of the crosstalk between bone and brain.

• Project/Area Number: 25670637
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: OKAWA Atsushi 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (30251507)
• Co-Investigator(Kenkyū-buntansha): ASAO Yoshinori 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (50345279)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 骨代謝 / 臓器連関 / 破骨細胞 / 成長ホルモン

Outline of Final Research Achievements

To evaluate the physiological role of renin-angiotensin system (RAS) in bone metabolism, we analyzed bone-specific RAS related gene deficient (CKO) mice. These mice showed low bone mass via decreasing of the bone formation, and the expression of bone formation markers in long bone were reduced. Furthermore, CKO mice decreased body weight compared with WT mice. These results suggest that RAS in bone metabolism regulates bone formation.

Research Products

• [Journal Article] Is closed suction drainage effective in early recovery of hip joint function? Comparative evaluation in one-stage bilateral total hip arthroplasty. (2015)
  • Author(s): Koyano G, Jinno T, Koga D, Hoshino C, Muneta T, Okawa A.
  • Journal Title: J Arthroplasty Volume: 30 Pages: 74-8
  • Peer Reviewed
• [Journal Article] Potential pathogenic mechanism for stress fractures of the bowed femoral shaft in the elderly: Mechanical analysis by the CT-based finite element method. (2014)
  • Author(s): Oh Y, Wakabayashi Y, Kurosa Y, Fujita K,Okawa A.
  • Journal Title: Injury. Volume: 45 Pages: 1764-71
  • Peer Reviewed
• [Journal Article] Modified K-line in magnetic resonance imaging predicts clinical outcome in patients with nonlordotic alignment after laminoplasty for cervical spondylotic myelopathy. (2014)
  • Author(s): Taniyama T, Hirai T, Yoshii T, Yamada T, Yasuda H, Saito M, Inose H, Kato T,Kawabata S, Okawa A.
  • Journal Title: Spine (Phila Pa 1976). Volume: 1;39(21):
  • Peer Reviewed
• [Journal Article] Genetic Study Group of Investigation Committee on Ossification of the Spinal Ligaments, Ikegawa S. A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine. (2014)
  • Author(s): Nakajima M, Takahashi A, Tsuji T, Karasugi T, Baba H, Uchida K, Kawabata S,Okawa A, et.al.
  • Journal Title: Nat Genet. Volume: 46(9) Pages: 1012-6
  • Peer Reviewed
• [Journal Article] The temporal and spatial development of vascularity in a healing displaced fracture. (2014)
  • Author(s): Yuasa M, Mignemi NA, Barnett JV, Cates JM, Nyman JS, Okawa A, Yoshii T, Schwartz HS, Stutz CM, Schoenecker JG.
  • Journal Title: Bone. Volume: 67 Pages: 208-21
  • Peer Reviewed
• [Journal Article] Severe kyphotic deformity resulting from collapses of cemented and adjacent vertebrae following percutaneous vertebroplasty using calcium phosphate cement (2014)
  • Author(s): Yoshii T, Ueki H, Kato T, Tomizawa S, Okawa A.
  • Journal Title: Skeletal Radiol. Volume: 43(10) Pages: 1477-80
  • Peer Reviewed
• [Journal Article] Spinal deformity caused by hyperimmunoglobulin E syndrome (2014)
  • Author(s): Araya N, Inose H, Kato T, Saito M, Sumiya S, Yamada T, Yoshii T, Kawabata S, Okawa A
  • Journal Title: J Neurosurg Spine. Volume: 21(2) Pages: 292-5
  • Peer Reviewed
• [Journal Article] Combined surgical and radiosurgical treatment for a symptomatic cervical metastasis in a case of malignant paraganglioma: a case report. (2013)
  • Author(s): Sasaki K, Inose H, Kawabata S, Yoshii T, Kato T, Saito M, Okawa A.
  • Journal Title: BMC Res Notes. Volume: 494 Issue: 1 Pages: 1-4
  • DOI: 10.1186/1756-0500-6-494
  • Peer Reviewed
• [Journal Article] Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling. (2013)
  • Author(s): Piao J, Tsuji K, Ochi H, Iwata M, Koga D, Okawa A, Morita S, Takeda S, Asou Y.
  • Journal Title: Ｓｃｉｅｎｔｉｆｉｃ Ｒｅｐｏｒｔ Volume: october 23 Issue: 1 Pages: 3022-3022
  • DOI: 10.1038/srep03022
  • Peer Reviewed
• [Journal Article] After repeated division, bone marrow stromal cells express inhibitory factors with osteogenic capabilities, and EphA5 is a primary candidate (2013)
  • Author(s): Yamada T, Yuasa M, Masaoka T, Taniyama T, Maehara H, Torigoe I, Yoshii T, Shinomiya K, Okawa A, Sotome S
  • Journal Title: Bone Volume: 57(2) Issue: 2 Pages: 343-54
  • DOI: 10.1016/j.bone.2013.08.028
  • Peer Reviewed
• [Journal Article] Sema3A regulates bone-mass accrual through sensory innervations (2013)
  • Author(s): Fukuda T, Takeda S, Xu R, Ochi H, Sunamura S, Sato T, Shibata S, Yoshida Y, Gu Z, Kimura A, Ma C, Xu C, Bando W, Fujita K, Shinomiya K, Hirai T, Asou Y, Enomoto M, Okano H, Okawa A, Itoh H
  • Journal Title: Nature. Volume: 497 Issue: 7450 Pages: 490-493
  • DOI: 10.1038/nature12115
  • Peer Reviewed
• [Journal Article] Initial Responses of Articular Tissues in a Murine High-Fat Diet-Induced Osteoarthritis Model: Pivotal Role of the IPFP as a Cytokine Fountain. (2013)
  • Author(s): Iwata M, Ochi H, Hara Y, Tagawa M, Koga D, Okawa A, Asou Y.
  • Journal Title: PLoS One Volume: 12 Issue: 4 Pages: e60706-e60706
  • DOI: 10.1371/journal.pone.0060706
  • Peer Reviewed
• [Journal Article] Dural closure for the treatment of superficial siderosis. (2013)
  • Author(s): Egawa S
  • Journal Title: Journal of Neurosurgery: Spine Volume: Apr;18(4) Issue: 4 Pages: 388-93
  • DOI: 10.3171/2013.1.spine12649
  • Peer Reviewed
• [Journal Article] Massive bone reconstruction with heat-treated bone graft loaded autologous bone marrow-derived strom al cells andβ-tricalcium phosphate composites in canine models (2013)
  • Author(s): Koyanagi H, Ae K, Maehara H, Yuasa M, Masaoka T, Yamada T, Taniyama T, Saito M, Funauchi Y, Yoshii T, Okawa A, Sotome S
  • Journal Title: J Orthop Res Volume: 31(8) Issue: 8 Pages: 1308-16
  • DOI: 10.1002/jor.22368
  • Peer Reviewed
• [Journal Article] Modified K-line in magnetic resonance imaging predicts insufficient decompression of cervical laminoplasty. (2013)
  • Author(s): Taniyama T
  • Journal Title: Spine Volume: 2013 Mar 15;38(6) Issue: 6 Pages: 496-501
  • DOI: 10.1097/brs.0b013e318273a4f7
  • Peer Reviewed