Clarification of the crosstalk between bone and brain.
Project/Area Number |
25670637
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Orthopaedic surgery
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
OKAWA Atsushi 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (30251507)
|
Co-Investigator(Kenkyū-buntansha) |
ASAO Yoshinori 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (50345279)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 骨代謝 / 臓器連関 / 破骨細胞 / 成長ホルモン |
Outline of Final Research Achievements |
To evaluate the physiological role of renin-angiotensin system (RAS) in bone metabolism, we analyzed bone-specific RAS related gene deficient (CKO) mice. These mice showed low bone mass via decreasing of the bone formation, and the expression of bone formation markers in long bone were reduced. Furthermore, CKO mice decreased body weight compared with WT mice. These results suggest that RAS in bone metabolism regulates bone formation.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] After repeated division, bone marrow stromal cells express inhibitory factors with osteogenic capabilities, and EphA5 is a primary candidate2013
Author(s)
Yamada T, Yuasa M, Masaoka T, Taniyama T, Maehara H, Torigoe I, Yoshii T, Shinomiya K, Okawa A, Sotome S
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Journal Title
Bone
Volume: 57(2)
Issue: 2
Pages: 343-54
DOI
Related Report
Peer Reviewed
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[Journal Article] Sema3A regulates bone-mass accrual through sensory innervations2013
Author(s)
Fukuda T, Takeda S, Xu R, Ochi H, Sunamura S, Sato T, Shibata S, Yoshida Y, Gu Z, Kimura A, Ma C, Xu C, Bando W, Fujita K, Shinomiya K, Hirai T, Asou Y, Enomoto M, Okano H, Okawa A, Itoh H
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Journal Title
Nature.
Volume: 497
Issue: 7450
Pages: 490-493
DOI
Related Report
Peer Reviewed
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[Journal Article] Massive bone reconstruction with heat-treated bone graft loaded autologous bone marrow-derived strom al cells andβ-tricalcium phosphate composites in canine models2013
Author(s)
Koyanagi H, Ae K, Maehara H, Yuasa M, Masaoka T, Yamada T, Taniyama T, Saito M, Funauchi Y, Yoshii T, Okawa A, Sotome S
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Journal Title
J Orthop Res
Volume: 31(8)
Issue: 8
Pages: 1308-16
DOI
Related Report
Peer Reviewed
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