The effectiveness and biocompatibility of iodine coated implant

• Project/Area Number: 25670640
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Kanazawa University
• Principal Investigator: HIDEJI Nishida 金沢大学, 医学系, 協力研究員 (50569374)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 抗菌インプラント / ヨード / インプラント / 抗菌

Outline of Final Research Achievements

Iodine-coated implants significantly inhibited colonization of the staphylococcus aureus. Biocompatibility of osteoblasts on instruments made by stainless steel, titanium, iodine coated titanium were evaluated. Stainless steel inhibited adhesion of osteoblast on the instruments. On the other hand, there is no significant difference among titanium, titanium with oxidation film, iodine-coated implants. More than 50% of iodine was detected in the implants four weeks after implantation in rabbits. Our results suggest that iodine-coated implants has antibacterial effects without toxicity to normal bone tissues.

Research Products

• [Journal Article] Salvage method for unplanned excision of soft tissue sarcoma: long-term results of second-look surgery following radio-hyperthermo-chemotherapy. (2015)
  • Author(s): Hayashi K, Yamada S, Inatani H, Okamoto H, Takeuchi A, Nishida H, Yamamoto N, Tsuchiya H, Otsuka T
  • Journal Title: Anticancer Res Volume: 35 Pages: 493-8
  • Peer Reviewed
• [Journal Article] Efficacy of triplet regimen antiemetic therapy for chemotherapy-induced nausea and vomiting (CINV) in bone and soft tissue sarcoma patients receiving highly emetogenic chemotherapy, and an efficacy comparison of single-shot palonosetron and consecutive-day granisetron for CINV in a randomized, single-blinded crossover study. (2015)
  • Author(s): Kimura H, Yamamoto N, Shirai T, Nishida H, Hayashi K, Tanzawa Y, Takeuchi A, Igarashi K, Inatani H, Shimozaki S, Kato T, Aoki Y, Higuchi T, Tsuchiya H.
  • Journal Title: Cancer Med Volume: 4 Pages: 333-341
  • DOI: 10.1002/cam4.373
  • Peer Reviewed / Open Access
• [Journal Article] Late recurrence of osteosarcoma: a report of two cases. (2014)
  • Author(s): Igarashi K, Yamamoto N, Shirai T, Nishida H, Hayashi K, Tanzawa Y, Kimura H, Takeuchi A, Miwa S, Inatani H, Shimozaki S, Kato T, Tsuchiya H
  • Journal Title: J Orthop Surg (Hong Kong) Volume: 22 Pages: 415-9
  • Peer Reviewed / Open Access
• [Journal Article] Outcomes and complications of reconstruction using tumor-bearing frozen autografts in patients with metastatic bone tumors. (2014)
  • Author(s): Miwa S, Takeuchi A, Shirai T, Yamamoto N, Hayashi K, Nishida H, Kimura H, Igarashi K, Tsuchiya H
  • Journal Title: Anticancer Res Volume: 34 Pages: 5569-77
  • Peer Reviewed
• [Journal Article] Synovial sarcoma in knee joint, mimicking low-grade sarcoma confirmed by molecular detection of SYT gene split. (2014)
  • Author(s): Kimura H, Yamamoto N, Nishida H, Hayashi K, Takeuchi A, Nojima T, Ikeda H, Sawada-Kitamura S, Tsuchiya H
  • Journal Title: Anticancer Res Volume: 34 Pages: 3105-11
  • Peer Reviewed
• [Journal Article] Antimicrobial megaprostheses supported with iodine. (2014)
  • Author(s): Shirai T, Tsuchiya H, Nishida H, Yamamoto N, Watanabe K, Nakase J, Terauchi R, Arai Y, Fujiwara H, Kubo T.
  • Journal Title: J Biomater Appl Volume: 29 Pages: 617-23
  • DOI: 10.1177/0885328214539365
  • Peer Reviewed
• [Journal Article] Diagnosis and treatment of low-grade osteosarcoma : experience with nine cases (2014)
  • Author(s): Hayashi K, Tsuchiya H, Yamamoto N, Shirai T, Nishida H, Takeuchi A, Kimura H, Miwa S, Inatani H, Okamoto H, Yamada S, Ikeda H, Sawada-Kitamura S, Nojima T, Ooi A, Otsuka T
  • Journal Title: Int J Clin Oncol Volume: Jul 24 Pages: 731-8
  • DOI: 10.1007/s10147-013-0592-z
  • Peer Reviewed
• [Presentation] 悪性骨軟部腫瘍に対する腫瘍破砕物質を抗原としTNF-αを併用した樹状細胞を用いた免疫療法 (2014)
  • Author(s): 西田英司、山本憲男、武内章彦、木村浩明、野村一世、土屋弘行
  • Organizer: 第５２回日本癌治療学術集会
  • Place of Presentation: パシフィコ横浜（横浜）
  • Year and Date: 2014-08-28 – 2014-08-30
• [Presentation] 標準治療抵抗性の悪性骨・軟部腫瘍に対する樹状細胞療法の可能性 (2014)
  • Author(s): 西田英司、山本憲男、白井寿治、林克洋、武内章彦、丹沢義一、木村浩明、三輪真嗣、五十嵐健太郎、下崎真吾、加藤貴士、青木裕、樋口貴史、土屋弘行
  • Organizer: 第４７回日本整形外科学会 骨・軟部腫瘍学術集会
  • Place of Presentation: 大阪国際会議場（大阪）
  • Year and Date: 2014-07-17 – 2014-07-18
• [Presentation] Immunotherapy based on dendritic cells is feasible for patients with malignant bone and soft tissue tumours (2014)
  • Author(s): Hideji Nishida, Norio Yamamoto, Toshiharu Shirai, Katsuhiro Hayashi, Akihiko Takeuchi, Yoshikazu Tanzawa, Hiroaki Kimura, Shinji Miwa, Kentaro Igarashi, Hiroyuki Tsuchiya
  • Organizer: 2014 American Society of Clinical Oncology
  • Place of Presentation: McCormick Place (Chicago)
  • Year and Date: 2014-05-30 – 2014-06-04
• [Presentation] Dendritic cells immunotherapy for patients with malignant bone and soft tissue tumours (2014)
  • Author(s): Hideji Nishida, Norio Yamamoto, Toshiharu Shirai, Katsuhiro Hayashi, Akihiko Takeuchi, Yoshikazu Tanzawa, Hiroaki Kimura, Shinji Miwa, Kentaro Igarashi, Hiroyuki Tsuchiya
  • Organizer: 第87回 日本整形外科学会総会
  • Place of Presentation: 神戸国際会議場（神戸）
  • Year and Date: 2014-05-22 – 2014-05-25