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Changes in expression of L-type calcium channel subunits in skeletal muscle with aging.

Research Project

Project/Area Number 25670641
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research InstitutionShinshu University

Principal Investigator

KATO Hiroyuki  信州大学, 学術研究院医学系, 教授 (40204490)

Co-Investigator(Kenkyū-buntansha) UCHIYAMA Shigeharu  信州大学, 学術研究院医学系, 准教授 (10242679)
YAMADE Mitsuhiko  信州大学, 学術研究院医学系, 教授 (10263237)
HIGUCHI Keiichi  信州大学, 学術研究院医学系, 教授 (20173156)
NAKADA Tsutomu  信州大学, 学術研究院医学系, 講師 (70452141)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsサルコペニア / 加齢 / L型カルシウムチャネル / 骨格筋 / 除神経 / 筋委縮 / L型Ca2+チャネル
Outline of Final Research Achievements

L-type calcium channels (LTCC) play an essential role in excitation-contraction coupling of skeletal muscle; however, it is controversial whether expression levels of LTCC subunits change in muscle atrophy. We investigated if this is the case in sarcopenia by using young (5-month-old) and aged (26-month-old) mice, and also in a mouse model of denervation-induced muscle atrophy. Absolute and specific force of tibialis anterior (TA) muscle significantly decreased with aging and denervation. Expression of CaV1.1 subunits, main subunits of LTCC, in TA was significantly lower whereas that of auxiliary CaVβ1 subunits was significantly higher in aged than young mice. In the case of denervation-induced muscle atrophy, expression of CaV1.1 subunits was unaltered whereas expression of CaVβ1 proteins but not mRNA increased. Thus, in various types of muscle atrophy, CaVβ1 protein expression may increase through the post-translational modification and be involved in the pathological process.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (1 results)

All 2016

All Presentation (1 results)

  • [Presentation] 除神経骨格筋におけるL型カルシウムチャネルβサブユニットの発現増加2016

    • Author(s)
      小松雅俊, 中田 勉, 山本竜星, 柏原俊英, 山田充彦
    • Organizer
      第89回 日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-03-10
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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