| Project/Area Number |
25670654
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUKUMITAU Hidefumi 岐阜薬科大学, 薬学部, 准教授 (00308280)
SOUMIYA Hitomi 岐阜薬科大学, 薬学部, 助教 (20548713)
KUNISADA Takahiro 岐阜大学, 医学部, 教授 (30205108)
TEZUKA Kenichi 岐阜大学, 医学部, 准教授 (50236973)
SHIBATA Toshiyuki 岐阜大学, 医学部, 教授 (50226172)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脊髄損傷 / 細胞移植 / FGF2 / 歯髄細胞 / 再生医療 / 神経栄養因子 |
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| Outline of Final Research Achievements |
In previous study, we have revealed that the locomotor function of rats are improved by injection of basic fibroblast growth factor (FGF2) into the spinal cord, immediately after the complete transection, via stimulating the proliferation of resident fibroblast-like cells {FGF2-induced fibroblast-like (FIF) cells]. On the other hand, transplantation of dental pulp cells (DPCs) also improved the locomoter functions: DPCs are derived from mesenchymal stem cells as FIF cells.
In this study, we investigated the possibility whether both treatments would provide additive and/or synergistic effects on the function recovery. The effect of the DPCs on the locomoter function was improved when the cells were treated with FGF2 before transplantation. Further investigations revealed that both FGF2 injection and DPCs transplantation are comparable and highly effective for locomoter function recovery: however, additive and/or synergistic effects were not observed in the combinations.
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