| Project/Area Number |
25670656
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
MAZDA Osam 京都府立医科大学, 医学(系)研究科(研究院), 教授 (00271164)
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| Co-Investigator(Renkei-kenkyūsha) |
ARAI Yuji 京都府立医科大学, 医学研究科, 講師 (50347449)
MORIHARA Toru 京都府立医科大学, 医学研究科, 講師 (90336735)
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| Project Period (FY) |
2013-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 骨軟骨代謝学 / 再生医療 / 骨芽細胞 / リプログラミング |
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| Research Abstract |
Bone remodeling is crucially involved in various pathological conditions of bone diseases including osteoporosis, bone disruption in rheumatoid arthritis,and bone healing after an surgical removal of bone tumor. If an enough number of active osteoblasts can be induced from patients' somatic cells and transplanted into the bone lesions, such procedures may be effective as a novel treatment for these bone diseases.
We have recently succeeded in inducing osteoblasts from normal human somatic cells.In this study we improved this technology to establish safer and feasible methods to induce human osteoblasts. As results, osteoblasts were successfully induced using nonviral procedures, and the resultant osteoblasts produced mineralized bone matrix at a high level. The present study may provide tailor-made osteoblasts that are suitable for transplantation, and propose novel regenerative medicine for osteoporotic fracture, bone remodeling after arthroplasty, and other bone diseases.
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