Bone regeneration based on direct reprogramming technologies
| Project/Area Number |
25670656
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
MAZDA Osam 京都府立医科大学, 医学(系)研究科(研究院), 教授 (00271164)
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| Co-Investigator(Renkei-kenkyūsha) |
ARAI Yuji 京都府立医科大学, 医学研究科, 講師 (50347449)
MORIHARA Toru 京都府立医科大学, 医学研究科, 講師 (90336735)
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| Project Period (FY) |
2013-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 骨軟骨代謝学 / 再生医療 / 骨芽細胞 / リプログラミング |
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| Research Abstract |
Bone remodeling is crucially involved in various pathological conditions of bone diseases including osteoporosis, bone disruption in rheumatoid arthritis,and bone healing after an surgical removal of bone tumor. If an enough number of active osteoblasts can be induced from patients' somatic cells and transplanted into the bone lesions, such procedures may be effective as a novel treatment for these bone diseases.
We have recently succeeded in inducing osteoblasts from normal human somatic cells.In this study we improved this technology to establish safer and feasible methods to induce human osteoblasts. As results, osteoblasts were successfully induced using nonviral procedures, and the resultant osteoblasts produced mineralized bone matrix at a high level. The present study may provide tailor-made osteoblasts that are suitable for transplantation, and propose novel regenerative medicine for osteoporotic fracture, bone remodeling after arthroplasty, and other bone diseases.
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Report
(2 results)
Research Products
(17 results)
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[Journal Article] Mild electrical stimulation with heat stimulation increase heat shock protein 70 in articular chondrocyte2013
Author(s)
Hiraoka N,Arai Y, Takahashi KA, Mazda O, Kishida T, Honjo K, Tsuchida S, Inoue H, Morino S, Suico MA, Kai H, Kubo T.
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Journal Title
J. Orthop. Res.
Volume: 17
Pages: 894-900
DOI
Related Report
Peer Reviewed
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[Presentation] Anti-inflammatory effects of lansoprazole by suppressing ROS production in murine macrophage RAW 264.7 cells2014
Author(s)
S. Ichimaru, S. Nakagawa, Y. Arai, S. Tsuchida, H. Inoue, T. Matsuki, Y. Mikami, T. Ikeda, R. Oda, O. Mazda, T. Kubo
Organizer
2014 Orthopaedic Research Society Annual Meeting
Place of Presentation
New Orleans, Louisiana, USA
Year and Date
2014-03-16
Related Report
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[Presentation] Sonoporation-mediated transduction of siRNA targeting TNF alpha ameliorated experimental arthritis2014
Author(s)
Inoue H, Arai Y, Nakagawa S, Saito M ,Tsuchida S, Inoue A, Matsuki T, Morihara T, Shirai T, Mazda, O, Kubo T
Organizer
60th Annual Meeting of OrthopaedicResearch Society
Place of Presentation
New Orleans, Louisiana, USA
Related Report
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[Presentation] Evaluation of femoral perfusion in a rabbit model of steroid-induced osteonecrosis with a high magnetic field MRI system2014
Author(s)
S. Hayashi, M. Fujioka, K. Ikoma, M. Saito, K. Ueshima, M. Ishida, M. Kuribayashi, A. Ikegami, O. Mazda and T. Kubo
Organizer
60th Annual Meeting of the Orthopaedic Research Society
Place of Presentation
New Orleans, Louisiana, USA
Related Report
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[Presentation] Effect of mechanical stress on the hypertrophic differentiation related gene expression in cultured chondrocytes2013
Author(s)
Inoue H, Arai Y, Terauchi R, Nakagawa S, Saito M, Hiraoka N, Tsuchida S, Matsuki T, Mazda Osam, Kubo T
Organizer
16th World Congress of the Osteoarthritis Research Society International
Place of Presentation
Philadelphia, USA.
Related Report
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