| Project/Area Number |
25670657
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Takasaki University of Health and Welfare |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | コラーゲン関節リウマチモデル / Imidazopyridine化合物 / GPR4 / プロトン受容体 / 関節リウマチ / pH感知性受容体 |
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| Outline of Final Research Achievements |
It is suggested that acidic microenvironment takes place in inflammatory sites in rheumatoid arthritis due to the stimulation of anaerobic glycolysis by infiltrated inflammatory cells. However, how acidification is involved in the pathophysiology remains unknown. In the current study, we planed to know the role of proton-sensing GPCRs, especially GPR4, in the development of arthritis. To this end, we analyzed the collagen-induced arthritis model using GPR4 knockout mouse. We also characterized chemicals which affect GPR4 activities in order to develop novel drugs related to GPR4.
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