In vivo imaging for joint, blood, and cerebrospinal fluid
| Project/Area Number |
25670662
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Spinal Injuries Center |
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Principal Investigator |
SHIBA KEIICHIRO 独立行政法人労働者健康福祉機構総合せき損センター(研究部), その他部局等, 研究員 (90574137)
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| Co-Investigator(Renkei-kenkyūsha) |
OKADA SEIJI 九州大学, 医学研究院, 准教授 (30448435)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | バイオイメージング |
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| Outline of Final Research Achievements |
The fluid biology including blood, cerebrospinal and joint fluid, is closely related with the pathophysiology of most disease in the field of orthopedic surgery. However, the evaluating method for it is relatively difficult due to a lack of basic researches using animal model. We attempted to establish in vivo imaging of fluid biology by using firefly luciferase and artificial albumin. We demonstrated that in vivo imaging of accumulated inflammatory cells can predict the prognosis in the hyperacute phase of spinal cord injury.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans.2014
Author(s)
Kobayakawa K, Kumamaru H, Saiwai H, Kubota K, Ohkawa Y, Kishimoto J, Yokota K, Ideta R, Shiba K, Tozaki-Saitoh H, Inoue K, Iwamoto Y, Okada S.
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Journal Title
Science Translatinal Medicine
Volume: 6
Pages: 1-14
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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