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In vivo imaging for joint, blood, and cerebrospinal fluid

Research Project

Project/Area Number 25670662
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research InstitutionSpinal Injuries Center

Principal Investigator

SHIBA KEIICHIRO  独立行政法人労働者健康福祉機構総合せき損センター(研究部), その他部局等, 研究員 (90574137)

Co-Investigator(Renkei-kenkyūsha) OKADA SEIJI  九州大学, 医学研究院, 准教授 (30448435)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsバイオイメージング
Outline of Final Research Achievements

The fluid biology including blood, cerebrospinal and joint fluid, is closely related with the pathophysiology of most disease in the field of orthopedic surgery. However, the evaluating method for it is relatively difficult due to a lack of basic researches using animal model. We attempted to establish in vivo imaging of fluid biology by using firefly luciferase and artificial albumin. We demonstrated that in vivo imaging of accumulated inflammatory cells can predict the prognosis in the hyperacute phase of spinal cord injury.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (12 results)

All 2015 2014 2013

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (3 results)

  • [Journal Article] Rapid progressive clinical deterioration of cervical spondylotic myelopathy.2015

    • Author(s)
      Morishita Y, et al.
    • Journal Title

      Spinal Cord

      Volume: 53(5) Issue: 5 Pages: 408-12

    • DOI

      10.1038/sc.2014.137

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of preservation of the C-6 spinous process and its paraspinal muscular attachment on the prevention of postoperative axial neck pain in C3-6 laminoplasty.2015

    • Author(s)
      Mori E, Ueta T, Maeda T, Yugue I, Kawano O, Shiba K.
    • Journal Title

      J Neurosurg Spine.

      Volume: 22 Issue: 3 Pages: 221-9

    • DOI

      10.3171/2014.11.spine131153

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiological outcome of short segment posterior instrumentation and fusion for thoracolumbar burst fractures.2015

    • Author(s)
      Vu TT, Morishita Y, et al
    • Journal Title

      Asian Spine J.

      Volume: 9(3) Issue: 3 Pages: 427-32

    • DOI

      10.4184/asj.2015.9.3.427

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans2014

    • Author(s)
      Kobayakawa K, Kumamaru H, Saiwai H, Kubota K, Ohkawa Y, Kishimoto J, Yokota K, Ideta R, Shiba K, Tozaki-Saitoh H, Inoue K, Iwamoto Y, Okada S
    • Journal Title

      Science Translational Medicine

      Volume: 6 Issue: 256 Pages: 256-256

    • DOI

      10.1126/scitranslmed.3009430

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Pathophysiological effects of lumbar instrumentation surgery on lumbosacral nerve roots in the vertebral foramen: measurement of local pressure of intervertebral foramen.2014

    • Author(s)
      Morishita Y, Maeda T, Ueta T, Naito M, Shiba K.
    • Journal Title

      Spine.

      Volume: 39 Issue: 21 Pages: E1256-E1260

    • DOI

      10.1097/brs.0000000000000520

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of Modic changes on spinal canal stenosis and segmental motion in cervical spine.2014

    • Author(s)
      Hayashi T, Daubs MD, Suzuki A, Phan K, Shiba K, Wang JC.
    • Journal Title

      ur Spine J.

      Volume: 23 Issue: 8 Pages: 1737-42

    • DOI

      10.1007/s00586-014-3406-8

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Risk factors for missed dynamic canal stenosis in the cervical spine.2013

    • Author(s)
      Hayashi T, Wang JC, Suzuki A, Takahashi S, Scott TP, Phan K, Lord EL, Ruangchainikom M, Shiba K, Daubs MD.
    • Journal Title

      Spine

      Volume: 39 Pages: 812-819

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Disturbance of rib cage development causes progressive thoracic scoliosis: the creation of a nonsurgical structural scoliosis model in mice.2013

    • Author(s)
      Kubota K, Doi T, Murata M, Kobayakawa K, Matsumoto Y, Harimaya K, Shiba K, Hashizume M, Iwamoto Y, Okada S.
    • Journal Title

      J Bone Joint Surg Am.

      Volume: 95

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Therapeutic activities of engrafted neural stem/precursor cells are not dormant in the chronically injured spinal cord.2013

    • Author(s)
      Kumamaru H, Saiwai H, Kubota K, Kobayakawa K, Yokota K, Ohkawa Y, Shiba K, Iwamoto Y, Okada S.
    • Journal Title

      Stem Cells.

      Volume: 31

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 頚髄損傷患者における嚥下障害の危険因子2015

    • Author(s)
      林  哲生、坂井 宏旭、出田 良輔、植田 尊善、前田  健、芝 啓一郎
    • Organizer
      第50回日本脊髄障害医学会
    • Place of Presentation
      東京都
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 受傷後 72 時間以内に診断された重篤麻痺を伴う 非骨傷性頚髄損傷に対する保存的治療経過2014

    • Author(s)
      森英治 、植田尊善 、前田健 、弓削 至 、河野修 、芝啓一郎
    • Organizer
      第49回日本脊髄障害医学会
    • Place of Presentation
      北海道旭川市
    • Year and Date
      2014-09-11 – 2014-09-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Facet joint angleが非骨傷性頚髄損傷の麻痺重症度に与える影響2013

    • Author(s)
      高尾恒彰、久保田健介、岡田誠司、森下雄一郎、前田健、植田尊善、林哲生、芝啓一郎
    • Organizer
      第42回日本脊椎脊髄病学会
    • Place of Presentation
      沖縄県宜野湾市
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2023-03-16  

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