| Project/Area Number |
25670668
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Niigata University |
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Principal Investigator |
KOHNO Tatsuro 新潟大学, 医歯学系, 准教授 (00313536)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIBUKI Katsuei 新潟大学, 脳研究所, 教授 (40146163)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | タニケットペイン / しびれ / フラビン蛍光蛋白 / 脊髄 / 大脳体性感覚 / フラビン蛋白蛍光イメージング / 脊髄後角 / 大脳体性感覚野 |
|---|
| Outline of Final Research Achievements |
Transient ischemia produces postischemic tingling sensation. Ischemia also produces nerve conduction block that may modulate spinal neural circuits. Neural activities were investigated using activity-dependent changes in endogenous fluorescence derived from mitochondrial flavoproteins. Ischemic treatment induced potentiation of the ipsilateral spinal responses to hindpaw stimulation. The present findings suggest that neural plasticity in the spinal cord shares the mechanisms, at least in part, with postischemic tingling sensation.
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