Elucidation of mechanism of tourniquet pain

Research Project

Project/Area Number	25670668
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Anesthesiology
Research Institution	Niigata University
Principal Investigator	KOHNO Tatsuro 新潟大学, 医歯学系, 准教授 (00313536)
Co-Investigator(Renkei-kenkyūsha)	SHIBUKI Katsuei 新潟大学, 脳研究所, 教授 (40146163)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	タニケットペイン / しびれ / フラビン蛍光蛋白 / 脊髄 / 大脳体性感覚 / フラビン蛋白蛍光イメージング / 脊髄後角 / 大脳体性感覚野
Outline of Final Research Achievements	Transient ischemia produces postischemic tingling sensation. Ischemia also produces nerve conduction block that may modulate spinal neural circuits. Neural activities were investigated using activity-dependent changes in endogenous fluorescence derived from mitochondrial flavoproteins. Ischemic treatment induced potentiation of the ipsilateral spinal responses to hindpaw stimulation. The present findings suggest that neural plasticity in the spinal cord shares the mechanisms, at least in part, with postischemic tingling sensation.