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Roles of dynorphin and nociceptin in the analgesic action of anesthetics

Research Project

Project/Area Number 25670671
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Anesthesiology
Research InstitutionKyoto University

Principal Investigator

FUKUDA Kazuhiko  京都大学, 医学(系)研究科(研究院), 教授 (90199224)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords亜酸化窒素 / オピオイド受容体 / 鎮痛 / 鎮静 / 鎮痛作用 / 鎮静作用 / ノックアウトマウス / ノシセプチン
Outline of Final Research Achievements

It has been previously reported that the opioid receptor is involved in the analgesic action of nitrous oxide, but it has not been clarified which type of the opioid receptor is involved. In this study, we have analyzed the pharmacological action of nitrous oxide in the kappa-opioid receptor (KOP)-knockout mice. The analgesic action of nitrous oxide was analyzed by acetic acid writhing test and hot-plate test, and was shown to be abolished in KOP-knockout mice. In contrast, the hypnotic action of nitrous oxide was not significantly different between the KOP-knockout mice and the wild-type mice. These results suggest that the analgesic action of nitrous oxide is mediated by KOP and that its hypnotic action is mediated by the other mechanism.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (1 results)

All 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Kappa-Opioid receptor mediates the antinociceptive effect of nitrous oxide in mice2014

    • Author(s)
      H. Fukagawa, T. Koyama and K. Fukuda
    • Journal Title

      British Journal of Anaesthesia

      Volume: 113 Issue: 6 Pages: 1032-1038

    • DOI

      10.1093/bja/aeu254

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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