| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
It has been previously reported that the opioid receptor is involved in the analgesic action of nitrous oxide, but it has not been clarified which type of the opioid receptor is involved. In this study, we have analyzed the pharmacological action of nitrous oxide in the kappa-opioid receptor (KOP)-knockout mice. The analgesic action of nitrous oxide was analyzed by acetic acid writhing test and hot-plate test, and was shown to be abolished in KOP-knockout mice. In contrast, the hypnotic action of nitrous oxide was not significantly different between the KOP-knockout mice and the wild-type mice. These results suggest that the analgesic action of nitrous oxide is mediated by KOP and that its hypnotic action is mediated by the other mechanism.
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