| Project/Area Number |
25670673
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HAYASE TOMO 札幌医科大学, 医学部, 助教 (20579007)
杉野 繁一 東北大学, 大学病院, 助教 (00423765)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 術後認知機能障害 / 麻酔科学 |
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| Outline of Final Research Achievements |
We investigated whether volatile anesthetics caused postoperative cognitive dysfunction (POCD). In humans, desflurane anesthesia showed a better mini mental examination score than did sevoflurane anesthesia. However, we could not find any genetic polymorphisms associated with cognitive function in humans. To examine the association between general anesthesia and POCD, we investigated whole mRNA expression in mouse hippocampal cells by a transcriptome-wide association study. While expression of the Lhx9 gene was suppressed by exposure to volatile anesthetics in juvenile mice, expression of Lhx9 gene was greatly enhanced by exposure to volatile anesthetics in adult mice. These results suggest that volatile anesthetics affect the differentiation of stem cells in the mouse hippocampus, and the results should be useful for exploring biomarkers of POCD.
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