Analysis of androgen-regulated natural antisense RNA for the diagnosis and treatment of prostate cancer
Project/Area Number |
25670678
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Urology
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Research Institution | The University of Tokyo |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
URANO Tomohiko 東京大学, 医学部附属病院, 講師 (20334386)
INOUE Satoshi 東京大学, 医学部附属病院, 特任教授 (40251251)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 分子腫瘍学 / 内分泌学 / 病態医化学 / ゲノム医科学 |
Outline of Final Research Achievements |
In this study, we investigated the role of antisense RNA, expressed in the antisense direction of protein coding gene, among long non-coding RNAs regulated by androgen receptor (AR) in prostate cancer. First, we identified a novel androgen-inducible non-coding RNA situated in the antisense region of CTBP1 gene, and then we named it as CTBP1-AS. We found the androgen-dependent accumulation of this antisense RNA in the nucleus of prostate cancer cells and the epigenetic mechanism for prostate cancer progression by CTBP1-AS. We also identified additional antisense RNAs regulated by androgen using directional RNA-seq analysis in prostate cancer cells.
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Report
(3 results)
Research Products
(24 results)
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[Journal Article] RUNX1, an androgen- and EZH2-regulated gene, has differential roles in AR-dependent and -independent prostate cancer2015
Author(s)
Takayama K, Suzuki T, Tsutsumi S, Fujimura T, Urano T, Takahashi S, Homma Y, Aburatani H, Inoue S
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Journal Title
Oncotarget
Volume: 6
Pages: 2263-2276
Related Report
Peer Reviewed
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[Journal Article] Systemic identification of estrogen-regulated genes in breast cancer cells through cap analysis of gene expression mapping.2014
Author(s)
Yamaga R, Ikeda K, Boele J, Horie-Inoue K, Takayama K, Urano T, Kaida K, Carninci P, Kawai J, Hayashizaki Y, Ouchi Y, de Hoon M, Inoue S
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Journal Title
Biochem Biophys Res Commun
Volume: 447
Pages: 531-536
DOI
Related Report
Peer Reviewed
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[Journal Article] Expression of androgen and estrogen signaling components and stem cell markers to predict cancer progression and cancer-specific survival in patients with metastatic prostate cancer.2014
Author(s)
Fujimura T, Takahashi S, Urano T, Takayama K, Sugihara T, Obinata D, Yamada Y, Kumagai J, Kume H, Ouchi Y, Inoue S, Homma Y
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Journal Title
Clin Cancer Res
Volume: 20
Pages: 4625-35
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] PAPD5-mediated 3' adenylation and subsequent degradation of oncomiR miR-21 is disrupted in proliferative disease2014
Author(s)
Boele J, Persson H, Shin JW, Ishizu Y, Newie I, Søkilde R, Hawkins SM, Coarfa C, Ikeda K, Takayama K, Horie-Inoue K, Ando Y, Burroughs AM, Sasaki C, Suzuki C, Sakai M, Aoki S, Ogawa A, Hasegawa A, Lizio M, Kaida K, Teusink B, Carninci P, Suzuki H, Inoue S, Gunaratne P, Rovira C, Hayashizaki Y, de Hoon M
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Journal Title
Proc Natl Acad Sci U S A
Volume: 111
Pages: 11467-11472
DOI
Related Report
Peer Reviewed
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[Journal Article] Pyrrole-imidazole polyamide targeted to break fusion sites in TMPRSS2 and ERG gene fusion represses prostate tumor growth.2014
Author(s)
Obinata D, Ito Akiko, Fujiwara K, Takayama K, Ashikari D, Murata Y, Yamaguchi K, Urano T, Fujimura T, Fukuda N, Soma M, Watanabe T, Nagase H, Inoue S, Takahashi S
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Journal Title
Cancer Science
Volume: 105
Pages: 1272-1278
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Androgen-responsive non-coding RNA CTBP1-AS promotes prostate cancer growth by epigenetic regulation2013
Author(s)
Takayama K, Horie-Inoue K, Katayama S, Suzuki T, Tsutsumi S, Ikeda K, Urano T, Fujimura T, Takagi K, Takahashi S, Homma Y, Ouchi Y, Aburatani H, Hayashizaki Y, Inoue S
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Journal Title
EMBO J.
Volume: 32
Pages: 1665-1680
DOI
Related Report
Peer Reviewed
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[Journal Article] MiR-424/503-mediated Rictor upregulation promotes tumor progression.2013
Author(s)
Oneyama C, Kito Y, Asai R, Ikeda J, Yoshida T, Okuzaki D, Kokuda R, Kakumoto K, Takayama K, Inoue S, Morii E, Okada M.
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Journal Title
DOI
Related Report
Peer Reviewed
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[Presentation] [Best Poster賞受賞] Expression of androgen and estrogen signaling components and stem cell markers is highly predictive of cancer progression of metastatic prostate cancer2014
Author(s)
Fujimura T, Takahashi S, Urano T, Kume H, Takayama K, Murata T, Yamada Y, Obinata D, Inoue S, Homma Y
Organizer
29th Annual Congress of the European Association of Urology
Place of Presentation
Stockholm, Sweden
Year and Date
2014-04-11 – 2014-04-15
Related Report
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[Presentation] Polyamide targeting transcription of long chain acyl-CoA synthetase 3: A novel therapeutic approach for prostate cancer2014
Author(s)
Obinata D, Takayama K, Fujiwara K, Fukuda N, Urano T, Ito A, Ashikari D, Murata T, Fujimura T, Ikeda K, Horie-Inoue K, Inoue S, Takahashi S
Organizer
29th Annual Congress of the European Association of Urology
Place of Presentation
Stockholm, Sweden
Year and Date
2014-04-11 – 2014-04-15
Related Report
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