| Project/Area Number |
25670684
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Yokohama City University |
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Principal Investigator |
KUBOTA Yoshinobu 横浜市立大学, 医学(系)研究科(研究院), 教授 (10106312)
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| Co-Investigator(Kenkyū-buntansha) |
YAO Masahiro 横浜市立大学, 医学（系）研究科（研究院）, 教授 (10106312)
矢尾 正祐 横浜市立大学, 医学(系)研究科(研究院), 教授 (00260787)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 膀胱癌 / 光力学治療 / 光触媒 / ヘマトポルフィリン / 可視光応答型光触媒 |
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| Outline of Final Research Achievements |
In this study, we tried to construct a novel nano-composite which consisted of visible light sensitive photocatalyst and Hematoporphyrin (Hp), and apply it to in situ diagnosis of bladder carcinoma.As results 1. We could successfully make Polyethylene glycol (PEG) modified TiO2 nanoparticles (PEG-TiO2) and a complex of TiO2/PEG and Hp (PEG-TiO2-Hp nanoparticles).2.The uptaken to human bladder cancer cells of these PEG-TiO2-Hp were confirmed and its fluorescence were around cytoplasm of the cells. The florescence intensity was stronger than when using Hp only. 3. The fluorescence intensity of treated cells were depended on treatment time and concentration of PEG-TiO2-Hp. These results suggested that PEG-TiO2-Hp could be potentially useful for apply to in situ diagnosis of bladder carcinoma.As future plan we will improve these compounds and will perform the toxic study of the conjugates for the application to human.
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