| Project/Area Number |
25670692
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Akita University |
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Principal Investigator |
YAMADA Yuichiro 秋田大学, 医学(系)研究科(研究院), 教授 (60283610)
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| Co-Investigator(Kenkyū-buntansha) |
TERADA Yukihiro 秋田大学, 大学院医学系研究科, 教授 (10260431)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | インクレチン / 不妊 |
|---|
| Outline of Final Research Achievements |
GIP, which is secreted from endocrine K cells of small intestine, not only stimulates insulin secretion from pancreatic beta-cells but also exerts various extra-pancreatic effects. We have shown that GIP receptors are highly expressed in testis, knockout of GIP receptor leads to decreased artificial fertilization, and expression of factor X is decreased in testis of GIP receptor KO mice and high fat-fed mice, that factor X may be involved in binding of sperm and oocytes. These results suggests that GIP signaling and factor X are participated in male infertility induced by high fat or over-eating.
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