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Effects of metformin on endometrial cell in PCOS patients

Research Project

Project/Area Number 25670694
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionChiba University

Principal Investigator

SHOZU Makio  千葉大学, 医学(系)研究科(研究院), 教授 (30226302)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords産婦人科学 / 生殖医学 / メトホルミン
Outline of Final Research Achievements

Metformin (met) has been used for ovulation induction. The conception rate of met is not, however, as high as would be expected from its higher ovulation rate. We tested the hypothesis that met inhibits cell proliferation and and the signal pathways for implantation, thus inhibiting embryo implantation. We examined the met actions on EME6E7TER-ERαcells that were derived from normal endometrial (EM) cells. Met did not affect the cell proliferation, whereas it inhibited proliferation and signals in EM cancer cells. Next we examined the effect of met in vivo. Tissue specimens were obtained from EM cancer patients and patients with PCOS who took met. Non-cancerous EM cells showed no change after met intake, whereas EM cancer cells showed a decreased proliferation and related signals. Our results suggest that EM cells are less sensitive to the suppressive action of met and, thus the inhibition of the proliferation signal is not the mechanism of the relatively low conception rate of met.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (16 results)

All 2015 2014 2013

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Acknowledgement Compliant: 2 results) Presentation (7 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] Metformin potentiates the anticancer effects of cisplatin under normoxic conditions in vitro2015

    • Author(s)
      TAKASHI UEHARA, AKIRA MITSUHASHI, NOBUHIDE TSURUOKA, MAKIO SHOZU1
    • Journal Title

      ONCOLOGY REPORTS

      Volume: 33 Issue: 2 Pages: 744-750

    • DOI

      10.3892/or.2014.3611

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Nonobese diabetic/severe combined immunodeficient murine xenograft model for human uterine leiomyoma.2014

    • Author(s)
      Wang G, Ishikawa H, Sone K, Kobayashi T, Kim JJ, Kurita T, Shozu M.
    • Journal Title

      Fertility and Sterility

      Volume: 印刷中 Issue: 5 Pages: 1485-1492.e3

    • DOI

      10.1016/j.fertnstert.2014.01.054

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of metformin on endometrial cancer cell growth in vivo: a preoperative prospective trial2014

    • Author(s)
      Akira Mitsuhashi, Takako Kiyokawa, Yasunori Sato, Makio Shozu
    • Journal Title

      Cancer

      Volume: 120 Issue: 19 Pages: 2986-2995

    • DOI

      10.1002/cncr.28853

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Lifestyle and osteoporosis in middle-aged and elderly women: Chiba bone survey2013

    • Author(s)
      Ichiro Tatsuno, Takashi Terano, Mitsugu Nakamura, Kiminori Suzuki, Kazuko Kubota, Jyunichi Yamaguchi, Tomohiko Yoshida, Sawako Suzuki, Tomaki Tanaka and Makio Shozu
    • Journal Title

      Endocr J.

      Volume: 60(5) Pages: 643-650

    • NAID

      10031184532

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tumor suppressive microRNA-218 inhibits cancer cell migration and invasion by targeting focal adhesion pathways in cervical squamous cell carcinoma2013

    • Author(s)
      Yamamoto N, Kinoshita T, Nohata N, Itesako T, Yoshino H, Enokida H, Nakagawa M, Shozu M, and Seki N
    • Journal Title

      International journal of oncology

      Volume: 42 Issue: 5 Pages: 1523-1532

    • DOI

      10.3892/ijo.2013.1851

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tumour-suppressive microRNA-29s inhibit cancer cell migration and invasion by targeting laminin-integrin signalling in head and neck squamous cell carcinoma.2013

    • Author(s)
      Kinoshita T, Nohata N, Hanazawa T, Kikkawa N, Yamamoto N, Yoshino H, Itesako T, Enokida H, Nakagawa M, Okamoto Y, Seki N.
    • Journal Title

      Br J Cancer

      Volume: 109 Issue: 10 Pages: 2636-2645

    • DOI

      10.1038/bjc.2013.607

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Assessment of intraoperative tube thoracostomy after diaphragmatic resection as part of debulking surgery for primary advanced-stage Mullerian cancer2013

    • Author(s)
      Kato K, Tate S, Nishikimi K, and Shozu M
    • Journal Title

      Gynecologic Oncology

      Volume: 131(1) Issue: 1 Pages: 32-35

    • DOI

      10.1016/j.ygyno.2013.07.091

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tumor-suppressive microRNA-29a inhibits cancer cell migration and invasion via targeting HSP47 in cervical squamous cell carcinoma.2013

    • Author(s)
      Yamamoto N, Kinoshita T, Nohata N, Yoshino H, Itesako T, Fujimura L, Mitsuhashi A, Usui H, Enokida H, Nakagawa M, Shozu M, and Seki N
    • Journal Title

      Int J Oncol

      Volume: 43 Issue: 6 Pages: 1855-1863

    • DOI

      10.3892/ijo.2013.2145

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Subrenal xenograft model for human uterine leiomyoma in non obese diabetic severe combined immunodeficient mice2014

    • Author(s)
      Ishikawa H, Gui Wen Wang, Kobayashi T, Kawarai Y and Shozu M
    • Organizer
      American Society ofr Reproductive Medicine (ASRM) 2014 Annual Meeting
    • Place of Presentation
      Honolulu, USA
    • Year and Date
      2014-10-18 – 2014-10-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 血中エストラジオール高値となる卵巣腫瘍2014

    • Author(s)
      松岡歩; 楯真一; 山本憲子; 錦見恭子; 碓井宏和; 三橋暁; 清川貴子; 生水真紀夫
    • Organizer
      第56回日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      栃木県総合文化センター(栃木県宇都宮市)
    • Year and Date
      2014-07-17 – 2014-07-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 子宮内膜症の発症機序を考える2014

    • Author(s)
      生水真紀夫
    • Organizer
      第6回文京子宮内膜症カンファレンス
    • Place of Presentation
      ホテル椿山荘東京(東京都文京区)
    • Year and Date
      2014-07-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 子宮内膜症におけるエピジェネティック機構の検討2014

    • Author(s)
      柿沼敏行、生水真紀夫
    • Organizer
      第66回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2014-04-18 – 2014-04-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 閉経前子宮体癌を合併した多嚢胞性卵巣症候群とインスリン抵抗性の関連および頻度の後方視的検討2014

    • Author(s)
      植原貴史、三橋暁、山本憲子、錦見恭子、楯真一、碓井宏和、石川博士、生水真紀夫
    • Organizer
      第66回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2014-04-18 – 2014-04-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 子宮内膜癌患者の耐糖能異常・インスリン抵抗性の前方視的検討2014

    • Author(s)
      三橋暁、塙真輔、山本憲子、植原貴史、錦見恭子、楯真一、碓井宏和、生水真紀夫
    • Organizer
      第66回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2014-04-18 – 2014-04-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 高アンドロゲン血症をきたした内分泌腫瘍の3例2014

    • Author(s)
      河原井麗正、石川博士、柿沼敏行、藤田真紀、金谷裕美、川野みどり、清川貴子、生水真紀夫
    • Organizer
      第66回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2014-04-18 – 2014-04-20
    • Related Report
      2014 Annual Research Report
  • [Book] Endometriosis Pathogenesis and Treatment (Harada Ed.)2014

    • Author(s)
      Hiroshi Ishikawa and Makio Shozu
    • Publisher
      Springer,
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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