| Project/Area Number |
25670695
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HIROTA YASUSHI 東京大学, 医学部附属病院, 講師 (40598653)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 着床 / 胚受容能 / 子宮 / プロゲステロン / プロゲステロン受容体 / 妊娠 / 細胞増殖 / マウスモデル / 産婦人科学 |
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| Outline of Final Research Achievements |
The embryo does not normally implant in the cervix but in the uterus. Stromal proliferation and epithelial differentiation, what we here call the proliferation/differentiation switching (PDS), occurs in the receptive uterus. We found that progesterone (P) signaling induces PDS and successful implantation in the receptive uterus, while elevated microRNA-200a leads to the reduction of PR expression and the promotion of P metabolism, and further non-responsiveness of PDS in the cervix. These findings indicate that P signaling deficiency by microRNA-200a confers cervical non-responsiveness to embryo implantation.
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