| Project/Area Number |
25670698
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHIRA Satoshi 信州大学, 学術研究院医学系(医学部附属病院), 講師 (90397315)
SHIOZAWA Tanri 信州大学, 学術研究院医学系, 教授 (20235493)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | Neuregulin-1 / 胎児肺成熟 / 胎盤絨毛内血管内皮細胞 / 臍帯静脈血管内皮細胞 / 低酸素 / 妊娠高血圧症候群 / ErbB |
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| Outline of Final Research Achievements |
We found the production of NRG-1β1 in vascular endothelial cells of the placental villi. The expression of NRG-1β1 was compared between the patient's groups, with maternal pregnancy induced hypertension (PIH; PIH group) or without maternal PIH (non-PIH group), and was significantly higher in the PIH group than in the non-PIH group. Western blotting revealed that the expression of NRG-1β1 in human umbilical vein endothelial cells (HUVEC) was enhanced by hypoxic condition. The blood NRG-1β1 level of umbilical vein collected at birth was significantly higher in PIH group than in non-PIH group (p <0.05). Furthermore, the maternal blood NRG-1β1 level was also higher in PIH group than in non-PIH group, but not significant. These findings suggest that NRG-1β1 is strongly expressed in vascular endothelial cells of placental villi and might be involved in fetal lung maturation.
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