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Development of an interface to refer OMICS information into clinic

Research Project

Project/Area Number 25670703
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionKinki University

Principal Investigator

MANDAI Masaki  近畿大学, 医学部, 教授 (80283597)

Co-Investigator(Kenkyū-buntansha) SHIMIZU Akira  京都大学, 医学部, 教授 (00162694)
YAMADA Ryo  京都大学, 医学部, 教授 (50301106)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords卵巣癌 / マイクロアレイ / 細胞内シグナル / バイオインフォマティクス / インターフェース / マイクロアレイ解析 / バーチャルカルテ
Outline of Final Research Achievements

Virtial chart for this study was created in the main computer to stock patient information safely. All the clinical and bioinformatics data except for personal identification were stored. Ovarian cancer specimen was subjected to the analysis of microarray in inhouse facility and all the data was stored in the main computer. Then, intracellular signals of each sample was calculated and refined into 1 to 10 scores, so that enables to estimate what kind of intracellular signal was activated in individual patient. These analysis was performed in a routine manner.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2015 2013 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 3 results) Presentation (2 results) (of which Invited: 1 results)

  • [Journal Article] The BMP signaling pathway leads to enhanced proliferation in serous ovarian cancer-a potential therapeutic target.2015

    • Author(s)
      Peng J, Yoshioka Y, Mandai M, et al
    • Journal Title

      Mol Carcinog

      Volume: Epub ahead of print Issue: 4 Pages: 1-11

    • DOI

      10.1002/mc.22283

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Invasion of uterine cervical squamous cell carcinoma cells is facilitated by locoregional interaction with cancer-associated fibroblasts via activating transforming growth factor-beta.2015

    • Author(s)
      Nagura M, Matsumura N, Baba T, Murakami R, Kharma B, Hamanishi J, Yamaguchi K, Abiko K, Koshiyama M, Mandai M, et al.
    • Journal Title

      Gynecol Oncol

      Volume: 136 Issue: 1 Pages: 104-111

    • DOI

      10.1016/j.ygyno.2014.11.075

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epigenetic determinants of ovarian clear cell carcinoma biology.2013

    • Author(s)
      Yamaguchi K, Huang Z, Matsumura N, Mandai M, Okamoto T, Baba T, Konishi I, Berchuck A, Murphy SK.
    • Journal Title

      Int J Cancer.

      Volume: - Issue: 3 Pages: 585-97

    • DOI

      10.1002/ijc.28701

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hepatocyte nuclear factor-1β promotes glucose uptake and glycolytic activity in ovarian clear carcinoma2013

    • Author(s)
      T Okamoto, M Mandai, N Matsumura, K Yamaguchi, H Kondoh, Y Amano, T Baba, J Hamanishi, K Abiko, K Kosaka, S K, Murphy, S Mori, I Konishi
    • Journal Title

      Molecular carcinogenesis

      Volume: Sep 17 Issue: 1 Pages: 1-15

    • DOI

      10.1002/mc.22072

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Utilization of genomic signatures to identify high efficacy candidate drugs for chemo-refractory endometrial cancers.2013

    • Author(s)
      Kharma B, Baba T, Mandai M, Matsumura N, Murphy SK, Kang HS, Yamanoi K, Hamanishi J, Yamaguchi K, Yoshioka Y, Konishi I.
    • Journal Title

      Int J Cancer.

      Volume: 133 Issue: 9 Pages: 2234-44

    • DOI

      10.1002/ijc.28220

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] PD-L1 on Tumor Cells Is Induced in Ascites and Promotes Peritoneal Dissemination of Ovarian Cancer through CTL Dysfunction.2013

    • Author(s)
      Abiko K, Mandai M, Hamanishi J, Yoshioka Y, Matsumura N, Baba T, Yamaguchi K, Murakami R, Yamamoto A, Kharma B, Kosaka K, Konishi I.
    • Journal Title

      Clin Cancer Res.

      Volume: 19 Issue: 6 Pages: 1363-1374

    • DOI

      10.1158/1078-0432.ccr-12-2199

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 卵巣高悪性漿液性腺癌のmolecular subtypeを反映する新しい病理組織学的分類

    • Author(s)
      村上隆介、ほか
    • Organizer
      第66回日本産科婦人科学会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] がん薬物療法の未来

    • Author(s)
      万代昌紀
    • Organizer
      がん分子標的治療フォーラム
    • Place of Presentation
      岡山
    • Related Report
      2013 Research-status Report
    • Invited

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Published: 2014-07-25   Modified: 2019-07-29  

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