| Project/Area Number |
25670704
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KATSUHIKO Naruse 奈良県立医科大学, 医学部, 助教 (70453165)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 羊水塞栓症 / 診断マーカー |
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| Outline of Final Research Achievements |
The levels of SCC and STN were measured by commercially available chemiluminescence enzyme immunoassay (CLIA) kit and radioimmunoassay (RIA) kit, respectively.The sensitivity in diagnosis of AFE was compared among SCC, STN and ZnCP1. We found significantly elevated serum levels of SCC in 4 cases with autopsy-proven AFE disease relative to control individuals with a normal delivery (112.0 ± 169.4 ng/ml vs. 4.4 ± 2.2 ng/ml, p=0.0009). Sensitivity and specificity of the SCC cut-off value (8.8 ng/ml) for differentiating patients with AFE from those with AFE-free individuals were 100% and 97%, respectively, whereas the sensitivities of ZnCP1 and STN were 75% and 25%. Compared with ZnCP1 and STN, serum SCC has a higher sensitivity in diagnosis of fatal AFE. More research is required for identification and validation of AFE.
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