| Project/Area Number |
25670707
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tokai University |
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Principal Investigator |
GOTO Yumiko 東海大学, 医学部, 助教 (50624574)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 卵巣明細胞腺癌 / TrkB / BDNF / アイソフォーム / 上皮間葉転換 / 卵巣癌 |
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| Outline of Final Research Achievements |
We focused on neurotrophin receptor TrkB which exists abundantly in ovary. We investigated TrkB expression in ovarian cancer and epithelial mesenchymal transition (EMT) signal induced by TrkB. We elucidated that TrkB over expression was observed in ovarian cancer, especially in clear cell adenocarcinoma by immunohistochemistry. We also found that TrkB-Shc and TrkB-T1 isoform which suppress tyrosine kinase signal decreased with advanced stage. We used cell lines of ovarian cancer and we obtained the same founding as above. We will analyse TrkB signal associated with EMT using these cell lines.
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