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New method for auditory nerve stimulation using optogenetics

Research Project

Project/Area Number 25670722
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionNational Rehabilitation Center for Persons with Disabilities

Principal Investigator

Takago Hideki  国立障害者リハビリテーションセンター(研究所), 研究所感覚機能系障害研究部, 研究室長 (70401354)

Co-Investigator(Kenkyū-buntansha) OSHIMA Tomoko (TAKAGO Tomoko)  国立障害者リハビリテーションセンター, 研究所感覚機能系障害研究部, 流動研究員 (50731783)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords光遺伝学 / オプトジェネティクス / 人工内耳 / 蝸牛 / 蝸牛神経 / パッチクランプ / 国際情報交換(ドイツ) / 有毛細胞
Outline of Final Research Achievements

Heterogeneity of excitatory postsynaptic currents in the mammalian auditory nerve fibers is the hallmark of cochlear physiology. In the present study, we found that uniquantal release of neurotransmitter glutamate through dynamic fusion pore controls the exocytosis at the inner hair cell afferent synapse. Furthermore we found that otoferlin (a causative gene for hereditary deafness DFNB9) plays an essential role for the heterogeneity of synaptic currents at this synapse.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (10 results)

All 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (7 results)

  • [Int'l Joint Research] ゲッティンゲン大学(ドイツ)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Developmental increase in hyperpolarization-activated current regulates intrinsic firing properties in rat vestibular ganglion cells.2015

    • Author(s)
      Yoshimoto R, Iwasaki S*, Takago H, Nakajima T, Sahara Y, Kitamura K.
    • Journal Title

      Neuroscience

      Volume: 284 Pages: 632-642

    • DOI

      10.1016/j.neuroscience.2014.10.034

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Uniquantal release through a dynamic fusion pore is a candidate mechanism of hair cell exocytosis2014

    • Author(s)
      Chapochnikov NM*, Takago H*, Huang CH, Pangrsic T, Khimich D, Neef J, Auge E, Goettfert F, Hell S, Wichmann C, Wolf F, Moser T (* Co-1st authors)
    • Journal Title

      Neuron

      Volume: 83 Issue: 6 Pages: 1389-1403

    • DOI

      10.1016/j.neuron.2014.08.003

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] マウス内有毛細胞リボンシナプスにおけるOtoferlinによる神経伝達物質放出の制御2015

    • Author(s)
      鷹合 秀輝
    • Organizer
      第116回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] Otoferlinはマウス内有毛細胞リボンシナプスにおいてエキソサイトーシスのモードを変える2015

    • Author(s)
      鷹合 秀輝, 大島-鷹合 知子, トビアス モーザー
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸国際会議場・展示場
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Otoferlin alters mode of exocytosis at the inner hair cell ribbon synapse2014

    • Author(s)
      Hideki Takago, Tobias Moser
    • Organizer
      The 1st annual meeting of the society for bioacoustics
    • Place of Presentation
      Doshisha Biwako Retreat Center
    • Year and Date
      2014-12-13 – 2014-12-14
    • Related Report
      2014 Research-status Report
  • [Presentation] Evaluation of synaptic function of otoferlin at the mouse inner hair cell ribbon synapse by postsynaptic recording2014

    • Author(s)
      Hideki Takago, Tobias Moser
    • Organizer
      Inner Ear Biology 2014 in Kyoto
    • Place of Presentation
      Kyoto International Conference Center
    • Year and Date
      2014-11-01 – 2014-11-04
    • Related Report
      2014 Research-status Report
  • [Presentation] マウス内有毛細胞リボンシナプスにおける神経伝達物質放出様式2014

    • Author(s)
      鷹合 秀輝
    • Organizer
      第115回日本耳 鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      ヒルトン福岡シーホーク
    • Year and Date
      2014-05-15 – 2014-05-17
    • Related Report
      2014 Research-status Report
  • [Presentation] マウス内有毛細胞リボンシナプスにおけるBassoonとシナプスリボンによるシナプス伝達の制御

    • Author(s)
      鷹合秀輝
    • Organizer
      第114回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      ロイトン札幌(札幌市)
    • Related Report
      2013 Research-status Report
  • [Presentation] マウス内有毛細胞求心性シナプスにおけるotoferlinの機能の分析

    • Author(s)
      鷹合秀輝, Tobias Moser
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島大学郡元キャンパス(鹿児島市)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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