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Accommodative IOL by ciliary stimulation

Research Project

Project/Area Number 25670730
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionOsaka University

Principal Investigator

FUJIKADO Takashi  大阪大学, 医学(系)研究科(研究院), 教授 (50243233)

Co-Investigator(Kenkyū-buntansha) MIHASHI Toshifumi  東京工業大学, 大学院総合理工学研究科, 特任教授 (20506266)
KANDA Hiroyuki  大阪大学, 大学院医学系研究科, 助教 (50570248)
MIYOSHI Tomomitsu  大阪大学, 大学院医学系研究科, 助教 (70314309)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords調節 / 短網様神経 / 電気刺激 / 老視 / 毛様体電気刺激 / 調節反応 / 瞳孔反応 / 調節可能眼内レンズ / 毛様体神経 / 高次収差
Outline of Final Research Achievements

Accommodation was evoked by cat short ciliary nerve stimulation with an amplitude (1 diopter) comparable to the physiological accommodation in cats. Accommodation was also induced by the scleral stimulation near the corneal limbus in cats with lower amplitude. Accommodative IOL using actuator made by polymer was developed and patented.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (19 results)

All 2015 2014 2013 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 4 results) Presentation (9 results) (of which Invited: 3 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Asymmetric wavefront aberrations and pupillary shapes induced by electrical stimulation of ciliary nerve in cats measured with compact wavefront aberrometer2015

    • Author(s)
      Miyagawa S, Mihashi T, Kanda H, Hirohara Y, Endo T, Morimoto T, Miyoshi T, Fujikado T
    • Journal Title

      PLoS One

      Volume: 9 Issue: 8 Pages: e105615-e105615

    • DOI

      10.1371/journal.pone.0105615

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of electrochemically treated bulk electrodes for a retinal prosthesis by examination of retinal intrinsic signals in cats2015

    • Author(s)
      Kanda H, Mihashi T, Miyoshi T, Hirohara Y, Morimoto T, Terasawa Y, Fujikado T.
    • Journal Title

      Jpn J Ophthalmol

      Volume: 58 Issue: 4 Pages: 309

    • DOI

      10.1007/s10384-014-0319-3

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of actual retinal images produced by misaligned aspheric intraocular lenses in a model eye.2014

    • Author(s)
      Fujikado T, Saika M
    • Journal Title

      Clinical Ophthalmology

      Volume: 2014(8) Pages: 2415-2423

    • DOI

      10.2147/opth.s72053

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characteristics of corneal topographic and pachymetric patterns in patients with pellucid marginal corneal degeneration2014

    • Author(s)
      Fuchihata M, Maeda N, Toda R, Koh S, Fujikado T, Nishida K
    • Journal Title

      Jpn J Ophthalmol

      Volume: 58-2 Issue: 2 Pages: 131-138

    • DOI

      10.1007/s10384-013-0291-3

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characteristics of retinal reflectance changes induced by transcorneal electrical stimulation in cat eyes2014

    • Author(s)
      Morimoto Takeshi, Kanda H, Miyoshi T, Hirohara Y, Mihashi T, Kitaguchi Y, Nishida K, Fujikado T
    • Journal Title

      PLOS ONE

      Volume: 9 Issue: 3 Pages: 1-11

    • DOI

      10.1371/journal.pone.0092186

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Feasibility of 2nd generation STS retinal prosthesis in dogs.2013

    • Author(s)
      Fujikado T, Kamei M, Sakaguchi H, Kanda H, Morimoto T, Nishida K, Kishima H, Maruo T, Oosawa K, Ozawa M, Nishida K
    • Journal Title

      Conf Proc IEEE Eng Med Biol Soc

      Volume: Jul Pages: 3119-3121

    • DOI

      10.1109/embc.2013.6610201

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Four discriminant models for detecting keratoconus pattern using Zernike coefficients of corneal aberrations2013

    • Author(s)
      Saika M, Maeda N, Hirohara Y, Mihashi T, Fujikado T, Nishida K
    • Journal Title

      Jpn J Ophthalmol

      Volume: 57 Issue: 6 Pages: 503

    • DOI

      10.1007/s10384-013-0269-1

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Optical imaging of retina in response to grating stimuli in cats2013

    • Author(s)
      Hirohara Y, Mihashi T, Kanda H, Morimoto T, Miyoshi T, Wolffsohn JS, Fujikado T
    • Journal Title

      Exp Eye Res

      Volume: 109 Pages: 1

    • DOI

      10.1016/j.exer.2013.01.007

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Pupillary shapes in response to electrical stimulation of the sclera of peripheral cornea in cats and porcines.2015

    • Author(s)
      Hirohara Y, Mihashi T, Miyoshi Miyagawa, S Kanda H, Sawai H, Fujikado T, Drew T Wolffsohn, JS.
    • Organizer
      ARVO2015
    • Place of Presentation
      Denver, USA
    • Year and Date
      2015-05-03 – 2015-05-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Accommodative response to electrical stimulation of the sclera of peripheral cornea in cats and porcines.2015

    • Author(s)
      Mihashi T, Hirohara Y, Miyoshi T, Miyagawa S, Kanda H, Sawai H, Fujikado T, Drew T Wolffsohn JS.
    • Organizer
      ARVO2015
    • Place of Presentation
      Denver, USA
    • Year and Date
      2015-05-03 – 2015-05-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Pupil and accommodation responses of the enucleated porcine eyes to electrical stimulation using a compact wavefront sensor.2014

    • Author(s)
      1.Mihashi, T, Hirohara, T, Miyoshi, T, Sawai, H, Drew, T, Wolffsohn, J
    • Organizer
      Visual & Physiological Optics (VPO)
    • Place of Presentation
      Wroclaw, Poland
    • Year and Date
      2014-08-25 – 2014-08-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Spatial extent of optical imaging response to light stimulation in the retina of cats.2014

    • Author(s)
      Mihashi T, Kanda H, Morimoto T, Miyoshi T, James S Wolffsohn, Fujikado T
    • Organizer
      ARVO2014
    • Place of Presentation
      Orland,USA
    • Year and Date
      2014-05-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Clinical application of adaptive optics fundus camera2014

    • Author(s)
      Fujiakdo Takashi
    • Organizer
      Japan Taiwan Bilateral Conference on Biomedical and Plasmonic Imaging
    • Place of Presentation
      Taipei Taiwan
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Feasibility of 2nd Generation STS Retinal Prosthesis with 49 Channel Electrode Array in Dogs2013

    • Author(s)
      Fujikado T, Kamei M, Kishima H, Maruo T, Osawa K, Ozawa M
    • Organizer
      ARVO2013
    • Place of Presentation
      Seattle, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Feasibility of 2nd Generation STS Retinal Prosthesis in dogs.2013

    • Author(s)
      Fujiakdo T, Kamei M, Sakaguchi H, Kanda H, Morimoto T, Nishida K, Kishima H, Maruo T, Oosawa K, Ozawa M
    • Organizer
      Artificial Vision 2013: The International Symposium on Visual Prosthetics
    • Place of Presentation
      Aachen,Germany
    • Related Report
      2013 Research-status Report
  • [Presentation] Effect of Low‐Additional Soft Contact Lenswith Decentered Optical Design on Myopia Progression inChildren2013

    • Author(s)
      Effect of Low‐Additional Soft Contact Lenswith Decentered Optical Design on Myopia Progression inChildren
    • Organizer
      Internatinal Myopia Conference
    • Place of Presentation
      California, USA
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Feasibility of 2nd Generation STS Retinal Prosthesis in Dogs2013

    • Author(s)
      Fujikado T, Kamei M, Sakaguchi H, Kanda H, Morimoto T, Nishida K, Kishima H, Maruo T, Oosawa K, Ozawa M, Nishida K
    • Organizer
      35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Osaka Japan
    • Related Report
      2013 Research-status Report
    • Invited
  • [Remarks] 大阪大学医学系研究科感覚機能形成学教室

    • URL

      http://www.med.osaka-u.ac.jp/pub/sensory/www/index.html

    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 眼機能補助装置2015

    • Inventor(s)
      三橋俊文、福間康文、藤野誠
    • Industrial Property Rights Holder
      三橋俊文、福間康文、藤野誠
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-050345
    • Filing Date
      2015-03-13
    • Related Report
      2014 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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