Strategy for the discovery of the candidate genes associated with the age-related macular degeneration and their therapeutic applications
| Project/Area Number |
25670733
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Tottori University |
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Principal Investigator |
BABA Takashi 鳥取大学, 医学部附属病院, 講師 (40304216)
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| Co-Investigator(Kenkyū-buntansha) |
井上 幸次 鳥取大学, 医学部, 教授 (10213183)
宮崎 大 鳥取大学, 医学部附属病院, 講師 (30346358)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 加齢黄斑変性 / 疾患モデルマウス / 血管新生 |
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| Outline of Final Research Achievements |
Under the comprehensive analysis of the aqueous humor from the age-related macular degeneration (AMD) patients, the candidate factor X was isolated, which has not been reported the participation in the angiogenesis. The role of the factor X in the pathogenesis of the AMD was investigated with the in vitro analysis using vasucular endothelial cells, the immunohistological analysis using the AMD model mice and the SNP analysis using the genome information from the AMD patients. It was reveled that the choroidal neovascularization (CNV) was inhibited by the blockage of the signal pathway under the factor X and the factor X receptor from the analysis of the AMD models using the knockout mice and the knockdown analysis by the siRNA. It was suggested that the CNVs were modified by the monocytes derived from the bone marrow cells depending on the factor X by the immunohistological analysis with the application of the fluorescein tagged bone marrow cells transplanted mice model.
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Report
(5 results)
Research Products
(32 results)
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[Journal Article] Steroid-Sparing Effect of 0.1% Tacrolimus Eye Drop for Treatment of Shield Ulcer and Corneal Epitheliopathy in Refractory Allergic Ocular Diseases2017
Author(s)
Miyazaki D, Fukushima A, Ohashi Y, Ebihara N, Uchio E, Okamoto S, Shoji J, Takamura E, Nakagawa Y, Namba K, Fujishima H.
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Journal Title
Ophthalmology
Volume: 124
Issue: 3
Pages: 287-294
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The effect of topical application of 0.15% ganciclovir gel on cytomegalovirus corneal endotheliitis.2016
Author(s)
Koizumi N, Miyazaki D, Inoue T, Ohtani F, Kandori-Inoue M, Inatomi T, Sotozono C, Nakagawa H, Horikiri T, Ueta M, Nakamura T, Inoue Y, Ohashi Y, Kinoshita S.
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Journal Title
Br J Ophthalmology
Volume: May 3
Issue: 2
Pages: 114-119
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Indoleamine 2,3-dioxygenase 1 in corneal endothelial cells limits herpes simplex virus type 1-induced acquired immune response2015
Author(s)
Haruki T, Miyazaki D, Inata K, Sasaki S, Yamamoto Y, Kandori M, Yakura K, Noguchi Y, Touge C, Ishikura R, Touge H, Yamagami S, Inoue Y
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Journal Title
Br J Ophthalmol.
Volume: 99
Issue: 10
Pages: 1435-1442
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Clinical features and management of cytomegalovirus corneal endotheliitis: analysis of 106 cases from the Japan corneal endotheliitis study2015
Author(s)
Koizumi N, Inatomi T, Suzuki T, Shiraishi A, Ohashi Y, Kandori M, Miyazaki D, Inoue Y, Soma T, Nishida K, Takase H, Sugita S, Mochizuki M, Kinoshita S; Japan Corneal Endotheliitis Study Group
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Journal Title
Br J Ophthalmol
Volume: 99
Issue: 1
Pages: 54-58
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Therapeutic effects of 0.1% tacrolimus eye drops for refractory allergic ocular diseases with proliferative lesion or corneal involvement.2014
Author(s)
Fukushima A, Ohashi Y, Ebihara N, Uchio E, Okamoto S, Kumagai N, Shoji J, Takamura E, Nakagawa Y, Namba K, Fujishima H, Miyazaki D
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Journal Title
Br J Ophthalmol.
Volume: 98
Issue: 8
Pages: 1023-1027
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 糖尿病と網膜症
Author(s)
馬場高志
Organizer
第7回臨床糖尿病セミナー
Place of Presentation
米子コンベンションセンター
Related Report
Invited
