Role of immune networks of corneal endothelium and trabecular meshwork
| Project/Area Number |
25670734
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Tottori University |
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Principal Investigator |
Miyazaki Dai 鳥取大学, 医学部附属病院, 講師 (30346358)
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| Co-Investigator(Kenkyū-buntansha) |
Inoue Yoshitsugu 鳥取大学医学部, 視覚病態学, 教授 (10213183)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 角膜内皮 |
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| Outline of Final Research Achievements |
Corneal endotheliitis and anterior chamber inflammation cause bullous keratopathy or secondary glaucoma leading to significant visual morbidity. Clinical findings on etiology of diseases strongly suggested strong association with endothelial inflammation and intraocular pressure elevation (IOP). Upon inflammatory stimulus including viral infection, corneal endothelial cells provoke strong innate immune response as well as activation of acquired immune arm. Analysis of the mediators released by innate immune response showed significant association with clinical parameters of secondary glaucoma. Analysis of trabecular meshwork cells upon these stimuli suggested their roll on remodeling of trabecular meshwork.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] The effect of topical application of 0.15% ganciclovir gel on cytomegalovirus corneal endotheliitis.2016
Author(s)
Koizumi N, Miyazaki D, Inoue T, Ohtani F, Kandori-Inoue M, Inatomi T, Sotozono C, Nakagawa H, Horikiri T, Ueta M, Nakamura T, Inoue Y, Ohashi Y, Kinoshita S.
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Journal Title
Br J Ophthalmology
Volume: May 3
Issue: 2
Pages: 114-119
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Indoleamine 2,3-dioxygenase 1 in corneal endothelial cells limits herpes simplex virus type 1-induced acquired immune response2015
Author(s)
Haruki T, Miyazaki D, Inata K, Sasaki S, Yamamoto Y, Kandori M, Yakura K, Noguchi Y, Touge C, Ishikura R, Touge H, Yamagami S, Inoue Y
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Journal Title
Br J Ophthalmol.
Volume: 99
Issue: 10
Pages: 1435-1442
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Clinical features and management of cytomegalovirus corneal endotheliitis: analysis of 106 cases from the Japan corneal endotheliitis study2015
Author(s)
Koizumi N, Inatomi T, Suzuki T, Shiraishi A, Ohashi Y, Kandori M, Miyazaki D, Inoue Y, Soma T, Nishida K, Takase H, Sugita S, Mochizuki M, Kinoshita S; Japan Corneal Endotheliitis Study Group
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Journal Title
Br J Ophthalmol
Volume: 99
Issue: 1
Pages: 54-58
DOI
Related Report
Peer Reviewed / Open Access
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