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The energy metabolism and tear secretion

Research Project

Project/Area Number 25670737
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionKeio University

Principal Investigator

TSUBOTA Kazuo  慶應義塾大学, 医学部, 教授 (40163878)

Research Collaborator TORII Hidemasa  慶應義塾大学, 医学部, 助教 (50445326)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsドライアイ / 涙腺 / 涙液
Outline of Final Research Achievements

The db/db mice were the animal model for a rodent model of type 2 diabetes. We investigated the molecular mechanism of tear secretion and metabolic changes.
We used db/db mice and their non-diabetic db/m mice in all experiments. Measurement of tear secretion was performed once a month with a phenol red thread. It was placed on the temporal side of the lower eyelid margin for 30 seconds. After measurement, the mice were sacrificed, lacrimal gland extirpated and lacrimal gland were used all experiments. Serum samples were collected for biochemical analysis. Body weight of db/db mice were significantly increased than db/m mice. In the biochemical analysis of the serum, blood glucoce were significantly higher in the db/db group than in the db/m. At the 3-month time-point of the experiment, tear secretion was decreased by the db/db mice compared to the db/m mice. We concluded those energy metabolism genes are key molecules for tear secretion.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (1 results)

All 2015

All Presentation (1 results)

  • [Presentation] 糖尿病モデルマウスを用いたSIRT1を介する涙腺機能の変化2015

    • Author(s)
      稲葉隆明、田中康久、渡辺光博、新村健、坪田一男
    • Organizer
      第15回日本抗加齢医学会総会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2015-05-29 – 2015-05-31
    • Related Report
      2014 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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