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The roles of Alarmin for the pathophysiology of Atopic Retinal Detachment

Research Project

Project/Area Number 25670738
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionJuntendo University

Principal Investigator

KAWANO Hiroyuki  順天堂大学, 医学部, 准教授 (70234094)

Co-Investigator(Kenkyū-buntansha) MATSUDA Akira  順天堂大学, 大学院医学研究科, 准教授 (00312348)
EBIHARA Nobuyuki  順天堂大学, 医学部, 教授 (20255699)
MORI Kazuhiko  京都府立医科大学, 大学院医学研究科, 講師 (50327805)
Co-Investigator(Renkei-kenkyūsha) NAKAE Susumu  東京大学, 医科学研究所, 准教授 (60450409)
TADA Nobuhiro  順天堂大学, 大学院医学研究科, 准教授 (50338315)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsアトピー / 網膜剥離 / アラーミン / アトピー性皮膚炎
Outline of Final Research Achievements

To elucidate roles 'Alarmins', which released from the injured tissue to alert danger to the neighbor healthy tissue, for the pathophysiological process of atopic retinal detachment, we investigated mouse retinal detachment models made by perforating retinal injury. We found positive immunolocalization of interleukin-33 (IL-33), a prototype of the alarmin, in the nuclei of the Muller glial cells of the healthy mouse retina. Upon perforating retinal injury, IL-33 released from the nuclei to the vitreo-retinal interface, and upregulate profibrotic genes in the injured retina. The results suggested that IL-33 may be a good therapeutic target or atopic retinal detachment in future.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (2 results)

All 2015 2014

All Presentation (2 results)

  • [Presentation] マウス網膜外傷モデルにおけるIL-33の役割2015

    • Author(s)
      杉田 丈夫,浅田 洋輔, 河野 博之, 海老原 伸行, 村上 晶, 中江 進, 松田 彰
    • Organizer
      第119回日本眼科学会総会
    • Place of Presentation
      札幌 ロイトン札幌・さっぽろ芸文館・札幌市教育文化会館
    • Year and Date
      2015-04-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] The role of interleukin-33 expression in retinal tissue2014

    • Author(s)
      Jobu Sugita, Hiroyuki Kawano, Akira Matsuda
    • Organizer
      Annual meeting of the association of research for vision and ophthalmology
    • Place of Presentation
      米国フロリダ州オーランド
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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