Evaluation of macular disease by choroidal structural analyses

• Project/Area Number: 25670739
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: KOIZUMI HIDEKI 東京女子医科大学, 医学部, 准講師 (20551500)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 脈絡膜 / 加齢黄斑変性 / 光干渉断層計 / 脈絡膜構造解析 / 脈絡膜厚

Outline of Final Research Achievements

The intra-choroidal structures were analysed with the images taken by a swept-sourde optical coherence tomography . It is known that both aging and myopic shift induce the decreased choroidal thickness, but the changes in intra-choroidal sturctures appeared to be different between the two conditions. After aflibercept therapy for neovascular age-related macular degeneration, not only the choroidal thickness, but also the intra-choroidal structures appeared to be significantly altered.

Research Products

• [Journal Article] Subfoveal Choroidal Thickness During Aflibercept Therapy for Neovascular Age-related Macular Degeneration: 12-Month Results (2016)
  • Author(s): Koizumi H, Kano M, Yamamoto A, Saito M, Maruko I, Sekiryu T, Okada AA, Iida T
  • Journal Title: Ophthalmology Volume: 123 Issue: 3 Pages: 617-624
  • DOI: 10.1016/j.ophtha.2015.10.039
  • Peer Reviewed
• [Journal Article] Aflibercept therapy for polypoidal choroidal vasculopathy: short-term results of a multicentre study. (2015)
  • Author(s): Koizumi H, et al.
  • Journal Title: British Journal of Ophthalmology Volume: 未定 Issue: 9 Pages: 1284-1288
  • DOI: 10.1136/bjophthalmol-2014-306432
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Short-term changes in choroidal thickness after aflibercept therapy for neovascular age-related macular degeneration. (2014)
  • Author(s): Koizumi H, Kano M, Yamamoto A, Saito M, Maruko I, Kawasaki R, Sekiryu T, Okada AA, Iida T.
  • Journal Title: Am J Ophthalmol. Volume: 159 Issue: 4 Pages: 627-633
  • DOI: 10.1016/j.ajo.2014.12.025
  • Peer Reviewed
• [Presentation] Choroidal Structural Analyses in CSC (2016)
  • Author(s): Hideki Koizumi
  • Organizer: International Retinal Imaging Symposium 4
  • Place of Presentation: 米国ロサンゼルス市
  • Year and Date: 2016-03-19
  • Int'l Joint Research / Invited
• [Presentation] Choroidal Structural Analyses After Half-Dose Photodynamic Therapy for Central Serous Chorioretinopathy (2015)
  • Author(s): Hideki Koizumi, Takahiko Izumi, Shozo Sonoda, Yohei Takahashi, Ichiro Maruko, Taiji Sakamoto, Tomohiro Iida
  • Organizer: American Academy of Ophthalmology Annual Meeting
  • Place of Presentation: 米国シカゴ市
  • Year and Date: 2015-11-16
  • Int'l Joint Research
• [Presentation] 滲出型加齢黄斑変性における脈絡膜層別解析および脈絡膜断層像二値化による評価 (2015)
  • Author(s): 髙橋 洋平、古泉 英貴、園田 祥三、和泉 雄彦、丸子 一朗、坂本 泰二、飯田 知弘
  • Organizer: 第119回日本眼科学会総会
  • Place of Presentation: ロイトン札幌（北海道札幌市）
  • Year and Date: 2015-04-17
• [Presentation] 加齢黄斑変性に対するアフリベルセプト療法前後の脈絡膜断層像二値化による評価 (2014)
  • Author(s): 高橋 洋平、古泉 英貴、丸子 一朗、園田 祥三、和泉 雄彦、坂本 泰二、飯田 知弘
  • Organizer: 第53回日本網膜硝子体学会総会
  • Place of Presentation: 大阪国際会議場（大阪府・大阪市）
  • Year and Date: 2014-11-28
• [Presentation] 加齢黄斑変性に対するアフリベルセプト硝子体内注射前後の脈絡膜層別解析 (2014)
  • Author(s): 古泉 英貴、和泉 雄彦、丸子 一朗、新井歌奈江、菅波 由花、林 殿宣、森永 将弘、小西 寛子、飯田 知弘
  • Organizer: 第68回日本臨床眼科学会
  • Place of Presentation: 神戸ポートピアホテル（兵庫県・神戸市）
  • Year and Date: 2014-11-15
• [Presentation] 正常眼における脈絡膜層別解析および脈絡膜断層像二値化による評価 (2014)
  • Author(s): 和泉 雄彦、古泉 英貴、園田 祥三、高橋 洋平、丸子 一朗、砂川 広海、坂本 泰二、飯田 知弘
  • Organizer: 第119回日本眼科学会総会
  • Place of Presentation: ロイトン札幌（北海道・札幌市）
  • Year and Date: 2014-04-17
• [Presentation] 非侵襲的眼底イメージングから考える加齢黄斑変性の病態
  • Author(s): 古泉 英貴
  • Organizer: 第30回日本眼循環学会
  • Place of Presentation: 東京都
  • Invited
• [Presentation] 滲出型加齢黄斑変性に対するアフリベルセプト硝子体内注射後の脈絡膜厚変化
  • Author(s): 古泉 英貴ら
  • Organizer: 第67回日本臨床眼科学会
  • Place of Presentation: 横浜市
• [Presentation] Recent Advancements of Choroidal Imaging in Age-Related Macular Degeneration
  • Author(s): Hideki Koizumi
  • Organizer: The 8th Asia Pacific Vitreous Retina Congress
  • Place of Presentation: 名古屋市
  • Invited
• [Presentation] Changes in Choroidal Thickness After Intravitreal Injections of Aflibercept for Exudative Age-Related Macular Degeneration: 3-Month Results
  • Author(s): Hideki Koizumi, et al.
  • Organizer: The 8th Asia Pacific Vitreous Retina Congress
  • Place of Presentation: 名古屋市