Development and pathological characterization of genetically modified macaque monkey with eye disease.
| Project/Area Number |
25670742
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | 独立行政法人国立病院機構(東京医療センター臨床研究センター) |
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Principal Investigator |
IWATA Takeshi 独立行政法人国立病院機構(東京医療センター臨床研究センター), 分子細胞生物学研究部, 部長 (90374157)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMOZAWA Nobuhiro 医薬基盤研究所, 霊長類医科学研究センター, 主任研究員 (50300786)
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| Project Period (FY) |
2013-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 霊長類 / ノックアウト / 遺伝子改変 / 疾患モデル動物 |
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| Research Abstract |
The structural and molecular characteristic of human eye is very unique to primate and different from other species. Development of animal model, which completely mimic the human eye diseases such as glaucoma, age-related macular degeneration and macular dystrophies has been difficult due to technical issues. In this research project we used the zinc finger nuclease (ZFN) technology to develop knockout or knockin macaque monkey. Developed monkeys will be maintained for pathological and visual function examination to understand the progression of the disease.
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Report
(2 results)
Research Products
(38 results)
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[Journal Article] Molecular characteristics of four Japanese cases with KCNV2 retinopathy : report of novel disease-causing variants2013
Author(s)
Fujinami K, Tsunoda K, Nakamura N, Kato Y, Noda T, Shinoda K, Tomita K, Hatase T, Usui T, Akahori M, Itabashi T, Iwata T, Ozawa Y, Tsubota K, Miyake Y.
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Journal Title
Molecular Vision
Volume: 19
Pages: 1580-90
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[Journal Article] Molecular characteristics of four Japanese cases with KCNV2 retinopathy: report of novel disease-causing variants.2013
Author(s)
Fujinami K, Tsunoda K, Nakamura N, Kato Y, Noda T, Shinoda K, Tomita K, Hatase T, Usui T, Akahori M, Itabashi T, Iwata T, Ozawa Y, Tsubota K, Miyake Y
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Journal Title
Molecular Vision
Volume: 19
Pages: 1580-1590
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Peer Reviewed
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[Presentation]
Organizer
International Society for Eye Research (ISER) Sarasota Symposium
Place of Presentation
(主催(世話人: Ernst Tamm, MD -Program Chair, Tailoi Chan-Ling, PhD, Mike Fautsch, PhD, Takeshi Iwata, PhD, Rob Nickells, PhD, Dan Stamer, PhD))
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