Genomic aberrations by chemoradiotherapy in children and its transfer to next generation
| Project/Area Number |
25670743
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatric surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
HIYAMA Eiso 広島大学, 自然科学研究支援開発センター, 教授 (00218744)
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| Co-Investigator(Kenkyū-buntansha) |
OGURA Kaoru 広島大学, 病院(医), 講師 (10346653)
ONITAKE Yoshiyuki 広島大学, 病院(医), 病院助教 (10448269)
UEDA Yuka 広島大学, 病院(医), 医科診療医 (70624641)
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| Project Period (FY) |
2013-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | ゲノム / 癌 / マイクロアレイ / 小児 / 放射線 |
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| Research Abstract |
To analyze the genomic transmission from the childhood cancer survivors to their future generation, pre- and post-therapeutic genomes in the 26 pairs of the patients and their children were examined using Cytoscan microarray which had more than 2,700,000 SNP (single nucleotide polymorphism) signals. All cases showed mutation, deletion, and insertion in 43 -3,123 (mean 623) loci in their genome and the numbers of altered loci is more in the patients who received radiotherapy. These genomic aberrations were significantly correlated with the use of anthracyclin chemotherapy.
In the analysis of their childhood genomes in the comparison with each parent genome, transferred aberrations were suspected in 3 of 24 pairs and all 3 cases were derived from female survivors. From these data, some of these aberration in the survivors were transmitted to the next generation.
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Report
(2 results)
Research Products
(34 results)
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[Journal Article] Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium2014
Author(s)
Lopez-Terrada D, Alaggio R, de Davila MT, Czauderna P, Hiyama E, Katzenstein H, Leuschner I, Malogolowkin M, Meyers R, Ranganathan S, Tanaka Y, Tomlinson G, Fabre M, Zimmermann A, Finegold MJ; Children's Oncology Group Liver Tumor Committee
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Journal Title
Modern Pathology
Volume: 27
Issue: 3
Pages: 472-491
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] RASSF1A methylation indicates a poor prognosis in hepatoblastoma patients2013
Author(s)
Honda S, Miyagi H, Suzuki H, Minato M, Haruta M, Kaneko Y, Hatanaka KC, Hiyama E, Kamijo T, Okada T, Taketomi A
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Journal Title
Pediatric Surgery International
Volume: 29
Issue: 11
Pages: 1147-1152
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A cisplatin plus pirarubicin-based JPLT2 chemotherapy for hepatoblastoma: experience and future of the Japanese Study Group for Pediatric Liver Tumor (JPLT)2013
Author(s)
Hiyama E, Ueda Y, Onitake Y, Kurihara S, Watanabe K, Hishiki T, Tajiri T, Ida K, Yano M, Kondo S, Oue T; Japanese Study Group for Pediatric Liver Tumor
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Journal Title
Pediatric Surgery International
Volume: 29
Issue: 10
Pages: 1071-1075
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Survival, surgical respectability, and late effects in the hepatoblastoma patients treated by cisplatin plus pirarubicin(CITA) chemotherapy2013
Author(s)
Hiyama E, Kamimatsuse A, Onitake Y, Ueda Y, Watanabe K, Hishiki T, Tajiri T, Ida K, Yano M, Kondo S, Oue T
Organizer
ASCO Annual ’ 13 Meeting
Place of Presentation
McComick Place（アメリカ シカゴ）
Related Report
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[Presentation] CHILDREN'S HEPATIC TUMOR INTERNATIONAL COLLABORATION (CHIC): NEW HEPATOBLASTOMA INTERNATIONAL RISK GROUPS (HB-IRG)2013
Author(s)
Meyers R, Haeberle B, Hiyama E, Maibach R, Krailo M, Feng Y, Yoshimura K, Rinaldi E, Ortali M, Saraceno D, Rangaswami A, Malogolowkin M, Perilongo G, Watanabe K, Schmid I, Aronson D, Von Schweinitz D, Leuschner I, Lopez-Terrada D, Tanaka Y, Czauderna P
Organizer
45th Congress of the International Society of Pediatric Oncology
Place of Presentation
Hong Kong Convention and Exhibition Centre(中国 香港）
Related Report
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[Presentation] FURTHER STUDY: IDENTIFICATION OF NEW CANDIDATE GENES IN PROGRESSION OF HEPATOBLASTOMA USING GENOME-WIDE ASSOCIATION STUDY2013
Author(s)
Hiyama E, Ueda Y, Onitake Y, Ida K, Ogura K, Kondo S, Kamijyo T, Watanabe K, Oue T, Hishiki T, Tajiri T, Horie H, Inoue T, Tanaka Y
Organizer
5th Congress of the International Society of Pediatric Oncology
Place of Presentation
Hong Kong Convention and Exhibition Centre(中国 香港）
Related Report
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