| Project/Area Number |
25670744
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatric surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
TAGUCHI Tomoaki 九州大学, 医学(系)研究科(研究院), 教授 (20197247)
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| Co-Investigator(Kenkyū-buntansha) |
KURODA Tatsuo 慶應義塾大学, 医学部(信濃町), 教授 (60170130)
NONAKA Kazuaki 九州大学, 歯学研究院, 教授 (90128067)
YAMAZA Takayoshi 九州大学, 歯学研究院, 講師 (80304814)
YAMAZA Haruyoshi 九州大学, 歯学研究院, 講師 (30336151)
YANAGI Yusuke 九州大学, 医学研究院, 共同研究員 (30596664)
IEIRI Satoshi 九州大学, 大学病院, 准教授 (00363359)
MIYOSHI Kina 九州大学, 大学病院, 医員 (20621709)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 移植・再生医療 / 歯学 / 神経科学 / 病理学 / 臨床 / ヒルシュスプルング病 / ヒルシュスプルング病類縁疾患 / ヒト脱落乳歯由来幹細胞 / SHED / 免疫寛容性 |
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| Outline of Final Research Achievements |
Hirschsprung's disease and its variants are known as disorders with intestinal peristaltic dysfunction developed from childhood. Congenital Hypoganglionosis (Hypo) is a representative disease of the variants with few intestinal ganglion cells. Currently, the patients are treated with bowel resection and enterostomy palliatively. Unfortunately, the survival rate show 78%, and the patients are hard to withdraw intravenous nutrition after the surgery. Small bowel transplantation is the only curative treatment for the patients; however, it is hard to perform in Japan, because of varied problems such as severe immune rejection and expensive cost resulting in severe outcomes.
Therefore the alternative therapeutics has been desired. Recently, stem cell-based regenerative therapy has been focused on a variety of refractory diseases. Currently, we transplanted stem cells into Hypo model mice, and improved the phenotype, pathological findings and electrophysiological motility.
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