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The role of neutrophil extracellular traps (NETs) in the pathogenesis of myocardial infarction

Research Project

Project/Area Number 25670757
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Emergency medicine
Research InstitutionUniversity of Tsukuba

Principal Investigator

HOMMA SATOSHI  筑波大学, 医学医療系, 教授 (00302422)

Co-Investigator(Kenkyū-buntansha) SAKAI Satoshi  筑波大学, 医学医療系, 講師 (30282362)
TAJIRI Kazuko  筑波大学, 医学医療系, 助教 (60633914)
KIMURA Taizo  筑波大学附属病院, 病院講師 (00636508)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords心筋梗塞 / 好中球細胞外トラップ / 好中球エラスターゼ / 好中球細胞外捕捉 / 炎症反応
Outline of Final Research Achievements

Neutrophil forms neutrophil extracellular traps (NETs), in which bacteria is effectively trapped and eliminated. The role of NETs in the pathogenesis of acute myocardial infarction (AMI), a representative of non-infectious inflammation, is unclear. We analyzed the inflammatory responses induced by AMI in neutrophil elastase gene knockout mice (KO), in which NETs formation is impaired. KO showed the reduced death due to cardiac rupture and higher survival. The profile of cytokine alteration showed the anti-inflammatory responses. Therefore, the presence of NETs is suggested to be pro-inflammatory and to promote the pathogenesis of AMI.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2014 2013

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (2 results)

  • [Journal Article] Calcitonin gene-related peptide protects the myocardium from ischemia induced by endothelin-1 : Intravital microscopic observation and 31P-MR spectroscopic studies2014

    • Author(s)
      Homma S, Kimura T, Sakai S, Yanagi KI, Miyauchi Y, Aonuma K, Miyauchi T
    • Journal Title

      Life Sci

      Volume: (in press) Issue: 2 Pages: 248-254

    • DOI

      10.1016/j.lfs.2014.02.024

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endothelin receptor antagonist exacerbates autoimmune myocarditis in mice2014

    • Author(s)
      Tajiri K, Sakai S, Kimura T, Machino-Ohtsuka T, Murakoshi N, Xu D, Wang Z, Sato A, Miyauchi T, Aonuma K
    • Journal Title

      Life Sci

      Volume: (in press) Issue: 2 Pages: 288-296

    • DOI

      10.1016/j.lfs.2014.01.007

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of peptidyl-prolyl isomerase Pin1 in the inhibitory effect of fluvastatin on endothelin-1-induced cardiomyocyte hypertrophy.2014

    • Author(s)
      Sakai S, Shimojo N, Kimura T, Tajiri K, Maruyama H, Homma S, Kuga K, Mizutani T, Aonuma K, Miyauchi T.
    • Journal Title

      Life Sci.

      Volume: 102 Issue: 2 Pages: 98-104

    • DOI

      10.1016/j.lfs.2014.03.018

    • NAID

      120007136696

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Tenascin-C modulates inflammatory response and aggravate ventricular remodeling after myocardial infarction in mice model2014

    • Author(s)
      Kimura T, et al.
    • Organizer
      American Heart Association Scientific Sessions 2014
    • Place of Presentation
      Chicago, IL, USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Elevated Blood pressure in resting daytime phase in A170/SQSTM1-knockout mice, a newly established obese model2013

    • Author(s)
      Sa, Homma S, et al.
    • Organizer
      13th International Conference on Endothelin
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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