| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
Controlling endothelial permeability are important in pathogenesis of the complications and outcome of inflammatory processes such as septic shock. Polymorphisms of permeability genes could alter outcomes of septic shock. Thus, we hypothesized that polymorphisms of genes that modulate endothelial permeability are associated with increased percent fluid overload and mortality of septic shock. We genotyped SNPs of 16 permeability genes (ANGPT1, ROBO1, ROBO4, CTNNB1, SLIT2N, F2R, FLT1, TEK, S1PR1, S1PR3, KDR, NPPA, VEGFA, RAC1, CDH5, and PROCR) in 520 patients with septic shock. We tested for associations of SNPs with 28-day mortality and percent fluid overload. We evaluated organ dysfunction as secondary outcomes of explanatory interest. Only A allele of rs4324901 of angiopoietin-1 was associated with increased 28-day mortality and fluid overload. ANGPT1 rs4324901 AA genotype patients had increased respiratory and neurologic dysfunction and need for increased renal replacement therapy.
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