Development of early diagnostic method that differentiates pediatric acute encephalopathy using mass spectrometry

Research Project

Project/Area Number	25670760
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Single-year Grants
Research Field	Emergency medicine
Research Institution	Kyoto University
Principal Investigator	KOIKE Kaoru 京都大学, 医学(系)研究科(研究院), 教授 (10267164)
Co-Investigator(Kenkyū-buntansha)	HIRAKAWA Keiko 日本医科大学, 医学部, 助教 (30165162)
Co-Investigator(Renkei-kenkyūsha)	MORIYAMA Tsuyoshi 東京工芸大学, 工学部, 准教授 (80449032) ASANO Takeshi 日本医科大学, 医学部, 准教授 (70277490) OHNO Youkichi 日本医科大学, 医学(系)研究科 (研究院), 教授 (70152220)
Project Period (FY)	2013-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywords	集中治療医学 / 医療 / 質量分析 / 核磁気共鳴 / 診断 / 多変量解析
Research Abstract	In children, it is difficult to distinguish "febrile seizure" from "acute encephalopathy" in the early phase. Our technique using proton nuclear magnetic resonance (NMR) spectra could differentiate cerebrospinal fluid (CSF) obtained from patients with acute encephalopathy, complex febrile seizures and simple febrile seizures. In the present study, we used our technique, analyzed CSF mass spectrometric (MS) data in the similar way and acquired a reasonable result. This technique proved to be a novel signal processing method that comprehensively handles the signal of electromagnetic waves obtained from complex mixture.