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Construction of medicine for radiation emergency system using iPS cell bank

Research Project

Project/Area Number 25670762
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Emergency medicine
Research InstitutionHiroshima University

Principal Investigator

Higashi Yukihito  広島大学, 原爆放射線医科学研究所, 教授 (40346490)

Co-Investigator(Kenkyū-buntansha) NOMA KENSUKE  広島大学, 原爆放射線医科学研究所, 助教 (00379893)
NAKASHIMA AYUMU  広島大学, 原爆放射線医科学研究所, 特任助教 (40448262)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords緊急被ばく医療 / 再生医療 / 細胞バンク / 再生療法
Outline of Final Research Achievements

In order to develop a regenerative medical system, by using the existing one, for radiation emergency, we attempted to manage the cell processing center to establish a system of a safe and secured iPS cell bank for radiation medicine. By using this iPS cell bank as the central leverage, we developed an education program for radiation emergency medicine, and to put this education program in practice, and to construct a network of regenerative medicine for radiation emergency medicine. We planed the trategies for promoting basic research and clinical research for radiation emergency medicine through international collaboration. Systematic promotion of the establishment of new therapies by comprehensively using cell therapy, cellular repair and regenerative biotechnology through collaboration with the medical experts in various fields such as teaching staff, including those in basic research, and graduate students, post-docs, research coordinators, doctors, nurses, etc.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (35 results)

All 2016 2015 2014 2013

All Journal Article (35 results) (of which Peer Reviewed: 35 results,  Open Access: 18 results,  Acknowledgement Compliant: 10 results)

  • [Journal Article] Combination of Flow-Mediated Vasodilation and Nitroglycerine-Induced Vasodilation Is More Effective for Prediction of Cardiovascular Events.2016

    • Author(s)
      Kajikawa M, Maruhashi T, Hida E, Iwamoto Y, Matsumoto T, Iwamoto A, Oda N,Kishimoto S, Matsui S, Hidaka T, Kihara Y, Chayama K, Goto C, Aibara Y, Nakashima A, Noma K, Higashi Y.
    • Journal Title

      Hypertension

      Volume: 67(5) Issue: 5 Pages: 1045-52

    • DOI

      10.1161/hypertensionaha.115.06839

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ratio of serum levels of AGEs to soluble form of RAGE is a predictor of endothelial function.2015

    • Author(s)
      Kajikawa M, Nakashima A, Fujimura N, Maruhashi T, Iwamoto Y, Iwamoto A, Matsumoto T, Oda N, Hidaka T, Kihara Y, Chayama K, Goto C, Aibara Y, Noma K, Takeuchi M, Matsui T, Yamagishi S, Higashi Y.
    • Journal Title

      Diabetes Care.

      Volume: 38(1) Issue: 1 Pages: 119-25

    • DOI

      10.2337/dc14-1435

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of aldosterone-producing adenoma on endothelial function and Rho-associated kinase activity in patients with primary aldosteronism.2015

    • Author(s)
      Matsumoto T, Oki K, Kajikawa M, Nakashima A, Maruhashi T, Iwamoto Y, Iwamoto A, Oda N, Hidaka T, Kihara Y, Kohno N, Chayama K, Goto C, Aibara Y, Noma K, Liao JK, Higashi Y.
    • Journal Title

      Hypertension.

      Volume: 65(4) Issue: 4 Pages: 841-8

    • DOI

      10.1161/hypertensionaha.114.05001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exogenous nitric oxide inhibits Rho-associated kinase activity in patients with angina pectoris: a randomized controlled trial.2015

    • Author(s)
      Maruhashi T, Noma K, Fujimura N, Kajikawa M, Matsumoto T, Hidaka T, Nakashima A, Kihara Y, Liao JK, Higashi Y.
    • Journal Title

      Hypertens Res.

      Volume: 38(7) Issue: 7 Pages: 485-90

    • DOI

      10.1038/hr.2015.24

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endothelial dysfunction is associated with the severity of cerebral small vessel disease.2015

    • Author(s)
      Nezu T, Hosomi N, Aoki S, Sugimoto T, Kubo S, Araki M, Matsushima H, Mukai T, Takahashi T, Maruyama H, Higashi Y, Matsumoto M.
    • Journal Title

      Hyperten Res.

      Volume: 38 Issue: 4 Pages: 291-297

    • DOI

      10.1038/hr.2015.4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of Endothelial Function2015

    • Author(s)
      Higashi Y.
    • Journal Title

      International Heart Journal

      Volume: 56 Issue: 2 Pages: 125-134

    • DOI

      10.1536/ihj.14-385

    • NAID

      130004941304

    • ISSN
      1349-2365, 1349-3299
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Depletion of Uric Acid Due to SLC22A12 (URAT1) Loss-of-Function Mutation Causes Endothelial Dysfunction in Hypouricemia2015

    • Author(s)
      Sugihara S, Hisatome I, Kuwabara M, Niwa K, Maharani N, Kato M, Ogino K, Hamada T, Ninomiya H, Higashi Y, Ichida K, Yamamoto K
    • Journal Title

      Circulation Journal

      Volume: 79 Issue: 5 Pages: 1125-1132

    • DOI

      10.1253/circj.CJ-14-1267

    • NAID

      130005066259

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration.2015

    • Author(s)
      Nakamura Y, Miyaki S, Ishitobi H, Matsuyama S, Nakasa T, Kamei N, Akimoto T, Higashi Y, Ochi M.
    • Journal Title

      FEBS Lett

      Volume: 589 Issue: 11 Pages: 1257-65

    • DOI

      10.1016/j.febslet.2015.03.031

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Rho-associated kinase activity is an independent predictor of cardiovascular events in acute coronary syndrome.2015

    • Author(s)
      Kajikawa M, Noma K, Nakashima A, Maruhashi T, Iwamoto Y, Matsumoto T, Iwamoto A, Oda N, Hidaka T, Kihara Y, Aibara Y, Chayama K, Sasaki S, Kato M, Dote K, Goto C, Liao JK, Higashi Y.
    • Journal Title

      Hypertension.

      Volume: 66(4) Issue: 4 Pages: 892-9

    • DOI

      10.1161/hypertensionaha.115.05587

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of a Low-Intensity Pulsed Ultrasound Device, SX-1001, on Clinical Symptoms in Buerger Disease With Limb Ischemia2015

    • Author(s)
      Higashi Y, Azuma N, Takeishi Y, Minamino T, Kihara Y, Node K, Sata M, Fukumoto Y, Origasa H, Matsuo H, Naritomi H, Fujita M, Shimizu W.
    • Journal Title

      International Heart Journal

      Volume: 56 Issue: 6 Pages: 632-638

    • DOI

      10.1536/ihj.15-191

    • NAID

      130005113045

    • ISSN
      1349-2365, 1349-3299
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reliability of measurement of endothelial function across multiple institutions and establishment of reference values in Japanese2015

    • Author(s)
      Tomiyama, H
    • Journal Title

      Atherosclerosis

      Volume: 242 Issue: 2 Pages: 433

    • DOI

      10.1016/j.atherosclerosis.2015.08.001

    • NAID

      120006881391

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Poor oral health behavior, decreased frequency of tooth brushing, is associated with endothelial dysfunction.2014

    • Author(s)
      Kajikawa M, Maruhashi T, Iwamoto Y, Iwamoto A, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Nakashima A, Goto C, Noma K, Taguchi A, Higashi Y.
    • Journal Title

      Circ J.

      Volume: 78 Pages: 950-954

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Borderline ankle-brachial index value of 0.91 to 0.99 is associated with endothelial dysfunction.2014

    • Author(s)
      Kajikawa M, Maruhashi T, Iwamoto Y, Iwamoto A, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Nakashima A, Goto C, Noma K, Higashi Y.
    • Journal Title

      Circ J.

      Volume: 78 Pages: 1740-1745

    • NAID

      130004926966

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Relationship between nitroglycerine-induced vasodilation and clinical severity of peripheral arterial disease.2014

    • Author(s)
      Maruhashi T, Nakashima A, Matsumoto T, Oda N, Iwamoto Y, Iwamoto A, Kajikawa M, Kihara Y, Chayama K, Goto C, Noma K, Higashi Y.
    • Journal Title

      Atherosclerosis.

      Volume: 235 Issue: 1 Pages: 65-70

    • DOI

      10.1016/j.atherosclerosis.2014.04.012

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Oxidative stress and endothelial dysfunction: clinical evidence and therapeutic implications.2014

    • Author(s)
      Higashi Y, Maruhashi T, Noma K, Kihara Y.
    • Journal Title

      Trends Cardiovasc Med.

      Volume: 24(4) Issue: 4 Pages: 165-9

    • DOI

      10.1016/j.tcm.2013.12.001

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Do incretins improve endothelial function (review)?2014

    • Author(s)
      Oyama J, Higashi Y, Node K.
    • Journal Title

      Cardiovasc Diabetol.

      Volume: 13 Issue: 3 Pages: 21-21

    • DOI

      10.3810/pgm.2013.05.2659

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A single consumption of curry improved postprandial endothelial function in healthy male subjects: a randomized, controlled crossover trial.2014

    • Author(s)
      Nakayama H, Tsuge N, Sawada H, Masamura N, Yamada S, Satomi S, Higashi Y.
    • Journal Title

      Nutr J.

      Volume: 13 Issue: 1 Pages: 67-67

    • DOI

      10.1186/1475-2891-13-67

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Autonomic nervous activation triggered during induction of reactive hyperemia exerts a greater influence on the measured reactive hyperemia index by peripheral arterial tonometry than on flow-mediated vasodilatation of the brachial artery in patients with hypertension.2014

    • Author(s)
      Tomiyama H, Yoshida M, Higashi Y, Takase B, Furumoto T, Kario K, Ohya Y, Yamashina A.
    • Journal Title

      Hypertens Res.

      Volume: 37 Issue: 10 Pages: 914-918

    • DOI

      10.1038/hr.2014.103

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Circulating endothelial progenitor cells and placental abruption in women with preeclampsia.2014

    • Author(s)
      Sakashita T, Higashi Y, Soga J, Fujiwara H, Kudo Y.
    • Journal Title

      Pregnancy Hypertens.

      Volume: 4 Pages: 203-208

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Critical role of exogenous nitric oxide in ROCK activity in vascular smooth muscle cells.2014

    • Author(s)
      Maruhashi T, Noma K, Fujimura N, Idei, N, Mikami S, Iwamoto Y, Kajikawa M, Matsumoto T, Hidaka T, Goto C, Kihara Y, Chayama K, Liao JK, Higashi Y.
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 10 Pages: e109017-e109017

    • DOI

      10.1371/journal.pone.0109017

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Promotion of skeletal muscle repair in rat skeletal muscle injury model by local injection of human adipose tissue-derived regenerative cells2013

    • Author(s)
      Ryo Mori, Kazunori Yokota
    • Journal Title

      Journal of Tissue Engineering and Regenerative Medicine

      Volume: in press Issue: 10 Pages: 1150-1160

    • DOI

      10.1002/term.1659

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rho-associated kinase is a predictor of a predictor of cardiovascular outcomes.2013

    • Author(s)
      Kajikawa M, Noma K, Maruhashi T, Mikami S, Iwamoto Y, Iwamoto A, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Nakashima A, Goto C, Liao JK, Higashi Y.
    • Journal Title

      Hypertension.

      Volume: 64 Issue: 4 Pages: 856-864

    • DOI

      10.1161/hypertensionaha.113.02296

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stroma-directed imatinib therapy impairs the tumor-promoting effect of bone marrow-derived mesenchymal stem cells in an orthotopic transplantation model of colon cancer2013

    • Author(s)
      Shinagawa K
    • Journal Title

      Int J Cancer

      Volume: 132 Issue: 4 Pages: 813-823

    • DOI

      10.1002/ijc.27735

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Flow-mediated vasodilation and anatomical variation of brachial artery (double brachial artery) in healthy subjects and atherosclerotic patients.2013

    • Author(s)
      Fujii Y, Teragawa H, Soga J, Fujimura N, Idei N, Hidaka T, Hata T, Mikami S, Maruhashi T, Iwamoto Y, Kihara Y, Chayama K, Noma K, Nakashima A, Goto C, Higashi Y.
    • Journal Title

      Circ J

      Volume: 77 Pages: 1073-1080

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of aldosterone-producing adenoma on cardiac structures in echocardiography.2013

    • Author(s)
      Hidaka T, Shiwa T, Fujii Y, Nishioka K, Utsunomiya H, Ishibashi K, Mitsuba N, Dohi Y, Oda N, Noma K, Kurisu S, Nakano Y, Yamamoto H, Ishida T, Higashi Y, Kihara Y.
    • Journal Title

      J Echocardiogr.

      Volume: 24 Pages: 185-190

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mesenchymal stem cells ameliorate experimental peritoneal fibrosis by suppressing inflammation and inhibiting TGF-beta1 signaling.2013

    • Author(s)
      Ueno, T., Nakashima, A., DOI:, S., Kawamoto, T., Honda, K., Yokoyama, Y., DOI:, T., Higashi, Y., Yorioka, N., Kato, Y., Kohno, N., and Masaki, T
    • Journal Title

      Kidney Int

      Volume: 84(2) Issue: 2 Pages: 297-307

    • DOI

      10.1038/ki.2013.81

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chronic intake of onion extract containing quercetin improved postprandial endothelial dysfunction in healthy men.2013

    • Author(s)
      Nakayama H, Tsuge N, Sawada H, Higashi Y.
    • Journal Title

      J Am Coll Nutr.

      Volume: 32 Issue: 3 Pages: 160-164

    • DOI

      10.1080/07315724.2013.797858

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Nitroglycerine-induced Vasodilation for Assessment of Vascular Function: A Comparison with Flow-mediated Vasodilation.2013

    • Author(s)
      Maruhashi T, Soga J, Idei N, Fujimura N, Mikami S, Iwamoto Y, Kajikawa M, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Noma K, Nakashima A, Goto C, Higashi Y.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 33 Issue: 6 Pages: 1401-1408

    • DOI

      10.1161/atvbaha.112.300934

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A novel noninvasive and simple method for assessment of endothelial function: Enclosed zone flow-mediated vasodilation (ezFMD) using an oscillation amplitude measurement2013

    • Author(s)
      Naomi Idei, Teiji Ukawa, Masato Kajikawa, Yumiko Iwamoto, Noritaka Fujimura, Tatsuya Maruhashi, Shinsuke Mikami, Takeshi Matsumoto, Yasuki Kihara, Kazuaki Chayama, Kensuke Noma, Ayumu Nakashima, Tsuneo Takayanagi, Haruka Morimoto, Toshio Tsuji, and Yukihito Higashi
    • Journal Title

      Atherosclerosis

      Volume: 229(2) Issue: 2 Pages: 324-330

    • DOI

      10.1016/j.atherosclerosis.2013.05.016

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Autologous Bone-Marrow Mesenchymal Stem Cell Implantation and Endothelial Function in a Rabbit Ischemic Limb Model2013

    • Author(s)
      Mikami S, Nakashima A, Nakagawa K, Maruhashi T, Iwamoto Y, Kajikawa M, Matsumoto T, Kihara Y, Chayama K, Noma K, Ochi M, Nishimura M, Tsuji K, Kato Y, Goto C, Higashi Y
    • Journal Title

      PLOS ONE

      Volume: 8(7) Issue: 7 Pages: e67739-e67739

    • DOI

      10.1371/journal.pone.0067739

    • NAID

      120006986197

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Age-dependent decrease in the chondrogenic potential of human bone marrow mesenchymal stem cells expanded with fibroblast growth factor-22013

    • Author(s)
      Kanawa M, Igarashi A, Ronald VS, Higashi Y, Kurihara H, Sugiyama M, Saskianti T, Pan H, Kato Y
    • Journal Title

      Cytotherapy

      Volume: 15(9) Issue: 9 Pages: 1062-72

    • DOI

      10.1016/j.jcyt.2013.03.015

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Resistin-Like Molecule β Is Abundantly Expressed in Foam Cells and Is Involved in Atherosclerosis Development.2013

    • Author(s)
      Kushiyama A, Sakoda H, Oue N, Okubo M, Nakatsu Y, Ono H, Fukushima T, Kamata H, Nishimura F, Kikuchi T, Fujishiro M, Nishiyama K, Aburatani H, Kushiyama S, Iizuka M, Taki N, Encinas J, Sentani K, Ogonuki N, Ogura A, Kawazu S, Yasui W, Higashi Y, Kurihara H, Katagiri H, Asano T.
    • Journal Title

      Arteriosclerosis, Thrombosis, and Vascular Biology

      Volume: 33 Issue: 8 Pages: 1986-1993

    • DOI

      10.1161/atvbaha.113.301546

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between oral health and the risk of lacunar infarction in Japanese adults.2013

    • Author(s)
      Taguchi A, Miki M, Muto A, Kubokawa K, Migita K, Higashi Y, Yoshinari N.
    • Journal Title

      Gerontology

      Volume: 59 Issue: 6 Pages: 499-506

    • DOI

      10.1159/000353707

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hyperuricemia is independently associated with endothelial dysfunction in postmenopausal women but not in premenopausal women.2013

    • Author(s)
      Maruhashi T, Nakashima A, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Kajikawa M, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Goto C, Noma K, Tomiyama H, Takase B, Yamashina A, Higashi Y.
    • Journal Title

      BMJ Open

      Volume: 2013 Nov 8;3(11) Issue: 11 Pages: e003659-e003659

    • DOI

      10.1136/bmjopen-2013-003659

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship between flow-mediated vasodilation and cardiovascular risk factors in a large community-based study.2013

    • Author(s)
      Maruhashi T, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Kajikawa M, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Noma K, Nakashima A, Goto C, Tomiyama H, Takase B, Yamashina A, Higashi Y.
    • Journal Title

      Heart

      Volume: 99(24) Issue: 24 Pages: 1837-1842

    • DOI

      10.1136/heartjnl-2013-304739

    • Related Report
      2013 Research-status Report
    • Peer Reviewed

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Published: 2014-07-25   Modified: 2019-07-29  

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