Osteocyte differentiation and function in bone homeostasis
Project/Area Number |
25670773
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Morphological basic dentistry
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
Nakashima Tomoki 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (00346959)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 骨生物学 / 骨恒常性 / 骨細胞 |
Outline of Final Research Achievements |
Bone is constantly renewed by the balanced action of osteoblastic bone formation and osteoclastic bone resorption both of which mainly occur at the bone surface. This restructuring process called "bone remodeling" is important not only for normal bone mass and strength, but also for mineral homeostasis. Osteocytes, the most numerous and least well studied bone cells, are stellate-shaped cells enclosed within the bone lacuno-canalicular network of bone. Based on the osteocyte location within the bone matrix and the cellular morphology, it is proposed that osteocytes potentially contribute to the regulation of bone remodeling in response to mechanical and endocrine stimuli. To identify the regulation factor of osteocyte differentiation and function, we performed a genome-wide screening of osteocytes and establishment of osteocytogenesis assay system.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Peyer's patches and mesenteric lymph nodes cooperatively promote enteropathy in a mouse model of food allergy.2014
Author(s)
Nakajima-Adachi, H., Kikuchi, A., Fujimura, Y., Shibahara, K., Makino, T., Goseki-Sone, M., Kihara-Fujioka, M., Nochi, T., Kurashima, Y., Igarashi, O., Yamamoto, M., Kunisawa, J., Toda, M., Kaminogawa, S., Sato, R., Kiyono, H., and Hachimura, S.
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Journal Title
PLoS One.
Volume: 9
Issue: 9
Pages: 108294-108294
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis.2014
Author(s)
Komatsu, N., Okamoto, K., Sawa, S., Nakashima, T., Oh-hora, M., Kodama, T., Tanaka, S., Bluestone, JA. and Takayanagi, H.
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Journal Title
Nature Medicine
Volume: 20
Issue: 1
Pages: 62-68
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] RANKL Biology2015
Author(s)
中島友紀
Organizer
日本リウマチ学会ベーシックリサーチカンファレン
Place of Presentation
東京大学鉄門記念講堂(東京)
Year and Date
2015-10-15
Related Report
Invited
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