Regulation of pathological bone destruction via transmembrane immune regulator Tim-3
| Project/Area Number |
25670780
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
KUKITA Toshio 九州大学, 歯学研究科(研究院), 教授 (70150464)
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| Co-Investigator(Kenkyū-buntansha) |
久木田 明子 佐賀大学, 医学部, 准教授 (30153266)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 炎症性骨破壊 / 免疫制御 / アジュバント関節炎 / Tim-3 / ガレクチン９ / 破骨細胞 / ガレクチン9 / Th1細胞 |
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| Outline of Final Research Achievements |
The purpose of this study is to analyze the expressional change of the Tim-3 and its ligand galectin-9 in the process of inflammatory bone destruction. In normal rats, Tim-3 expression was well consistent with the location of osteoclasts and their mononuclear precursors. Expression of Tim-3 ligand galectin-9 was detected in the bone marrow periphery facing to the bone surface. In contrast, expression of Tim-3 and its ligand galectin-9 was detected in whole areas of marrow cavity. To know the function of Tim-3 in osteoclastogenesis, galectin-9 was added to the cultures of evaluating osteoclast differntiation in vitro. Galectin-9, markedly inhibited osteoclastogenesis. When galectin-9 was injected around the ankle joint of the rats with adjuvant-induced arthritis, inflammatory bone destruction was marketly suppressed. This research shows the possibility of developing a novel therapy using an new regulatory system of Tim-3/galectin-9.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] Involvement of CXCL14 in osteolytic bone metastasis from lung cancer.2014
Author(s)
Takiguchi S, Korenaga N, Inoue K, Sugi E, Kataoka Y, Matsusue K, Futagami K, Li YJ, Kukita T, Teramoto N, Iguchi H.
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Journal Title
Int J Oncol.
Volume: 44（4)
Issue: 4
Pages: 1316-1324
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Kadowaki T, Kido MA, Hatakeyama J, Okamoto K, Tsukuba T, Yamamoto K. Defective adipose tissue development associated with hepatomegaly in cathepsin E-deficient mice fed a high-fat diet.2014
Author(s)
Kadowaki T, Kido MA, Hatakeyama J, Okamoto K, Tsukuba T, Yamamoto K.
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Journal Title
Biochem Biophys Res Commun.
Volume: 446(1)
Issue: 1
Pages: 212-217
DOI
Related Report
Peer Reviewed
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