| Project/Area Number |
25670781
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Saitama Medical University |
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Principal Investigator |
TANAKA Motomu 埼玉医科大学, 医学部, 客員講師 (70197482)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIKAWA Keisuke 埼玉医科大学, 医学部, 助教 (10435860)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMIZU Takao 東京大学, 医学系研究科, 特任教授 (80127092)
KITA Yoshihiro 東京大学, 医学系研究科, 准教授 (20401028)
NOMURA Ryota 大阪大学, 歯学系研究科, 講師 (90437385)
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| Research Collaborator |
TAKAHASHI Marika
YAMAMOTO Shinji
IWASA Kensuke
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 口腔内細菌 / 多発性硬化症 |
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| Outline of Final Research Achievements |
Oral bacteria are related to not only oral disease but also systemic disorder. We investigated the effect of Streptococcus mutans and Porphyromonas gingivalis, pathogenic bacteria of dental caries and periodontitis, respectively, on neuronal disease. We found that endotoxin derived from Porphyromonas gingivalis exacerbated myelin decrease. These data suggest that periodontitis are risk factor for Multiple sclerosis, neuronal disease characterized by myelin decrease.
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