| Project/Area Number |
25670786
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional basic dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Tetsu 東北大学, 大学院歯学研究科, 教授 (60226850)
WASHIO Jumpei 東北大学, 大学院歯学研究科, 助教 (20400260)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 癌 / メタボローム解析 / ワールブルグ効果 / グルタミノリシス / 口腔扁平上皮癌 / 糖代謝 / アミノ酸代謝 |
|---|
| Outline of Final Research Achievements |
This study aimed to characterize the metabolic system of oral squamous cell carcinoma (OSCC) by metabolome analysis. The metabolome profiles were obtained from OSCC and its surrounding normal tissues, using CE-TOFMS. Enhancement of glucose consumption and lactate production (Warburg effect) was observed in OSCC tissues, while the downstream intermediates in the glycolysis were decreased and glutamine degradation (glutaminolysis) was enhanced . These results suggest that OSCC tissues supply metabolic intermediates from glucose for biosynthesis via the pentose phosphate cycle and obtain energy from glutamine with lactate production.
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