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Exploration of seeds for development of a new drug targeting Bone-Vascular-Spleen axis

Research Project

Project/Area Number 25670793
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Functional basic dentistry
Research InstitutionMatsumoto Dental University

Principal Investigator

UDAGAWA Nobuyuki  松本歯科大学, 歯学部, 教授 (70245801)

Co-Investigator(Kenkyū-buntansha) NINOMIYA Tadashi  松本歯科大学, 総合歯科医学研究所, 講師 (00360222)
NAKAMICHI Yuko  松本歯科大学, 総合歯科医学研究所, 講師 (20350829)
NAKAMURA Midori  松本歯科大学, 歯学部, 准教授 (90278177)
UEHARA Syunsuke  松本歯科大学, 歯学部, 講師 (90434480)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords破骨細胞 / 骨芽細胞 / マクロファージ / 脾臓 / RANKL / M-CSF / IL-34 / ミクログリア / 皮膚 / 脳 / ビタミンD / 単球 / 血管
Outline of Final Research Achievements

(1)To clarify the role of spleen in bone metabolism, M-CSF-deficient mice and wild-type mice were subjected to splenectomy or a sham-operation. Splenectomy completely suppressed osteoclastogenesis in M-CSF-deficient mice. In contrast, splenectomy moderately suppressed osteoclastogenesis in wild-type mice.
(2)Comparing the gene expression profiles of IL-34-positive and IL-34-negative vascular endothelial cells identifies differentially expressed genes. We focused on top-ranked genes which possess leading signal peptide for secretion and membrane-anchoring.We are now addressing functional analyses of these genes.
(3)To elucidate mechanisms underlying the age-associated increase of IL-34 expressions in several tissues, we tried to establish the culture system for IL-34-positive vascular endothelial cells. However, the expression level of IL-34 gradually decreased in long-term culture.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (10 results)

All 2015 2014 2013 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 4 results) Presentation (2 results) (of which Invited: 2 results) Book (1 results)

  • [Journal Article] The dynamin inhibitor dynasore inhibits bone resorption by rapidly disrupting actin rings of osteoclasts.2015

    • Author(s)
      Thirkonda, G.J., Uehara, S., Nakayama, T., Yamashita, T., Nakamura, Y., Mizoguchi, T., Yagami, K., Takahashi, N., Udagawa, N., Kobayashi, Y.
    • Journal Title

      J. Bone Miner. Metab.

      Volume: 33

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Noncanonical Wnt5a enhances Wnt/-catenin signaling during osteogenesis.2014

    • Author(s)
      Okamoto, M., Udagawa, N., Yamashita, T., Nakamichi, Y., Uehara, S., Kato, H., Saito, N., Minami, Y., Takahashi, N., Kobayashi, Y.
    • Journal Title

      Sci. report

      Volume: 4 Issue: 1 Pages: 4493-4493

    • DOI

      10.1038/srep04493

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Arctigenin inhibits osteoclast differentiation and function by suppressing both calcineurin-dependent and osteoblastic cell-dependent NFATc1 pathways.2014

    • Author(s)
      Yamashita T, Uehara S, Udagawa N, Li F, Kadota S, Esumi H, Kobayashi Y, Takahashi N
    • Journal Title

      PLoS One

      Volume: 9 Issue: 1 Pages: 85878-85878

    • DOI

      10.1371/journal.pone.0085878

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] VitaminD endocrine system and osteoclasts.2013

    • Author(s)
      Takahashi N, Udagawa N, Suda T
    • Journal Title

      BoneKEy Reports

      Volume: 3 Pages: 495-495

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Stimulation of bone formation in cortical bone of mice treated with a receptor activator of nuclear factor-κB ligand (RANKL)-binding peptide that possesses osteoclastogenesis inhibitory activity.2013

    • Author(s)
      Furuya Y, Inagaki A, Khan M, Mori K, Penninger JM, Nakamura M, Udagawa N, Aoki K, Ohya K, Uchida K, Yasuda H
    • Journal Title

      J Biol Chem

      Volume: 288 Issue: 8 Pages: 5562-5571

    • DOI

      10.1074/jbc.m112.426080

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Osteoprotegerin-deficient male mice as a model for severe alveolar bone loss: Comparison with RANKL-overexpressing transgenic male mice.2013

    • Author(s)
      Koide M et al.
    • Journal Title

      Endocrinology

      Volume: 190 Issue: 2 Pages: 773-782

    • DOI

      10.1210/en.2012-1928

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] IL-34 and CSF-1 similarities and differences2013

    • Author(s)
      Nakamichi Y, Udagawa N, Takahashi N
    • Journal Title

      J Bone Miner Metab

      Volume: 31 Issue: 5 Pages: 486-495

    • DOI

      10.1007/s00774-013-0476-3

    • NAID

      10031201682

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Bone tissue as systemic organ supporting a life-correlation between periodontitis and osteoporosis.2014

    • Author(s)
      Udagawa N
    • Organizer
      The 2nd Bio-Rheumatology International Congress(BRIC 2014)& The 9th GARN Meeting Moscow ~Eurasia Rheumatology Congress~
    • Place of Presentation
      Russian Federation
    • Year and Date
      2014-06-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 生命を支えている臓器としての骨-歯周疾患と骨粗鬆症の関連-

    • Author(s)
      宇田川信之
    • Organizer
      第55回歯科基礎医学会学術大会・総会(日本学術会議シンポジウム)
    • Place of Presentation
      岡山(岡山コンベンションセンター)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] Encyclopedia of Human Body 3rd Edition2015

    • Author(s)
      Takahashi, N., Mizoguchi, T., Nakamichi, Y., Kobayashi, Y., Nakamura, M., Hofstetter, W., Udagawa, N.
    • Related Report
      2014 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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