• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The promotion mechanisms of diabetic nephropathy by Porphyromonas gingivalis lipopolysaccharide via toll-like receptors in glomerular endothelial cells.

Research Project

Project/Area Number 25670803
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionFukuoka Dental College

Principal Investigator

SAWA YOSHIHIKO  福岡歯科大学, 歯学部, 教授 (70271666)

Co-Investigator(Kenkyū-buntansha) HATAKEYAMA Yuji  福岡歯科大学, 口腔歯学部, 准教授 (40302161)
OKA Kyoko  福岡歯科大学, 口腔歯学部, 准教授 (60452778)
敦賀 英知  福岡歯科大学, 口腔歯学部, 教授 (30295901)
谷口 邦久  福岡歯科大学, 口腔歯学部, 教授 (90105685)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords糖尿病 / toll-like receptor / 腎糸球体 / 糖尿病性腎症 / AGE / 歯周病 / 予防医学 / TLR拮抗剤 / 血管内皮細胞 / Porphyromonas gingivalis / 予防
Outline of Final Research Achievements

We showed that the glomerulus blood endothelial cells with Diabetes mellitus expressed toll-like receptors (TLRs), and that all of the diabetic mice injected with Porphyromonas gingivalis LPS, which is the ligand of TLRs and the causative agent of periodontitis, died for diabetic nephropathy within all survival periods of non-diabetic mice with the LPS likewise. Diabetic nephropathy might be a cause in oral bacteria entering in the circulation because bacteria easily enter into the blood vessels of the patients with severe periodontitis by toothbrushing. The bacteria entering into the circulation at the intestine go to the liver but at the oral and maxillofacial circulation bacteria anatomically reach to kidney. Now, we began the study to prophylactically inhibit diabetic nephropathy by using the TLR antagonists.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (22 results)

All 2014 2013 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 1 results) Presentation (13 results)

  • [Journal Article] Expression of toll-like receptor 2 in glomerular endothelial cells and promotion of diabetic nephropathy by Porphyromonas gingivalis lipopolysaccharide.2014

    • Author(s)
      Yoshihiko Sawa, Shunsuke Takata, Yuji Hatakeyama, Hiroyuki Ishikawa, Eichi Tsuruga.
    • Journal Title

      PLOS ONE

      Volume: e97165 Issue: 5 Pages: e97165-e97165

    • DOI

      10.1371/journal.pone.0097165

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of toll-like receptor 2 in glomerular endothelial cells and promotion of diabetic nephropathy by Porphyromonas gingivalis lipopolysaccharide2014

    • Author(s)
      Sawa Y, Takata S, Hatakeyama Y, Ishikawa H, Tsuruga E
    • Journal Title

      PLoS One

      Volume: 1 Pages: 1-1

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Microfibril-Associated Glycoprotein-1 Controls Human Ciliary Zonule Development <i>In Vitro</i>2014

    • Author(s)
      Fujita T, Tsuruga E, Yamanouchi K, Sawa Y, Ishikawa H
    • Journal Title

      ACTA HISTOCHEMICA ET CYTOCHEMICA

      Volume: 47 Issue: 1 Pages: 11-17

    • DOI

      10.1267/ahc.13038

    • NAID

      130003390845

    • ISSN
      0044-5991, 1347-5800
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Altered Dynamics in the Renal Lymphatic Circulation of Type 1 and Type 2 Diabetic Mice2013

    • Author(s)
      Takanobu Uchiyama
    • Journal Title

      ACTA HISTOCHEMICA ET CYTOCHEMICA

      Volume: 46 Issue: 2 Pages: 97-104

    • DOI

      10.1267/ahc.13006

    • NAID

      130003361076

    • ISSN
      0044-5991, 1347-5800
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Expression of Toll-Like Receptor 4 in Glomerular Endothelial Cells under Diabetic Conditions2013

    • Author(s)
      Shunsuke Takata
    • Journal Title

      ACTA HISTOCHEMICA ET CYTOCHEMICA

      Volume: 46 Issue: 1 Pages: 35-42

    • DOI

      10.1267/ahc.13002

    • NAID

      130003361070

    • ISSN
      0044-5991, 1347-5800
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Distribution of Podoplanin-Expressing Cells in the Mouse Nervous Systems2013

    • Author(s)
      Tomooka M, Kaji C, Kojima H, Sawa Y
    • Journal Title

      ACTA HISTOCHEMICA ET CYTOCHEMICA

      Volume: 46 Issue: 6 Pages: 171-177

    • DOI

      10.1267/ahc.13035

    • NAID

      130003381871

    • ISSN
      0044-5991, 1347-5800
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Matrix Metalloproteinase-2 Degrades Fibrillin-1 and Fibrillin-2 of Oxytalan Fibers in the Human Eye and Periodontal Ligaments <i>In Vitro</i>2013

    • Author(s)
      Kawagoe M, Tsuruga E, Oka K, Sawa Y, Ishikawa H
    • Journal Title

      ACTA HISTOCHEMICA ET CYTOCHEMICA

      Volume: 46 Issue: 5 Pages: 153-159

    • DOI

      10.1267/ahc.13024

    • NAID

      130003381869

    • ISSN
      0044-5991, 1347-5800
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Risk factors to cause tooth formation anomalies in chemotherapy of paediatric cancers.2013

    • Author(s)
      Sawa Nishimura
    • Journal Title

      European Journal of Cancer Care

      Volume: 22 Issue: 3 Pages: 353-360

    • DOI

      10.1111/ecc.12038

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Quantitative evaluation of myofibroblast apoptosis during wound healing in rat palate after post-operative administration of basic fibroblast growth factor (bFGF)2013

    • Author(s)
      Hata Y, Ishikawa H, Ueki T, Kajii TS, Tamaoki S, Tsuruga E, Sawa Y, Taniguchi K
    • Journal Title

      Acta Odontol Scand

      Volume: 71(6) Issue: 6 Pages: 1501-1507

    • DOI

      10.3109/00016357.2013.773370

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 歯周病原性LPSによるTLRを介した糖尿病性腎症の促進について2014

    • Author(s)
      髙田俊輔, 梶原弘一郎, 石川博之, 沢 禎彦
    • Organizer
      第41回福岡歯科大学学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-12-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Porphyromonas gingivalis由来LPSは腎糸球体のTLR2/4を介して糖尿病性腎症を促進する2014

    • Author(s)
      髙田俊輔, 梶原弘一郎,沢 禎彦, 石川博之
    • Organizer
      第73回日本矯正歯科学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2014-10-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 歯周病原菌由来TLRリガンドによる糖尿病性腎症の促進2014

    • Author(s)
      髙田俊輔, 梶原弘一郎, 石川博之, 沢 禎彦
    • Organizer
      第56回歯科基礎医学会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Severe Periodontal Disease exacerbate Diabetic Nephropathy through Toll-like receptor (TLR) 2 and TLR42014

    • Author(s)
      髙田俊輔, 梶原弘一郎,沢 禎彦, 石川博之
    • Organizer
      第57回春季日本歯周病学会学術集会
    • Place of Presentation
      岐阜
    • Year and Date
      2014-05-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 糖尿病マウス腎糸球体における歯周病原菌由来LPSによるTLR2/4依存性サイトカイン発現2014

    • Author(s)
      髙田俊輔, 梶原弘一郎,沢 禎彦, 石川博之
    • Organizer
      日本顕微鏡学会第70回記念学術講演会
    • Place of Presentation
      千葉
    • Year and Date
      2014-05-12
    • Related Report
      2014 Annual Research Report 2013 Research-status Report
  • [Presentation] 106. Severe Periodontal Disease exacerbate Diabetic Nephropathy through Toll-like receptor (TLR) 2 and TLR2014

    • Author(s)
      高田俊輔、内山貴誠、石川博之、沢禎彦
    • Organizer
      第57回春季日本歯周病学会学術集会
    • Place of Presentation
      岐阜
    • Related Report
      2013 Research-status Report
  • [Presentation] 糖尿病モデルマウス腎糸球体におけるTLR2とTLR4の発現2013

    • Author(s)
      高田俊輔、内山貴誠、石川博之、沢禎彦
    • Organizer
      第28回日本糖尿病合併症学会
    • Place of Presentation
      旭川
    • Related Report
      2013 Research-status Report
  • [Presentation] I型とII型糖尿病モデルマウスにおける腎リンパ管新生2013

    • Author(s)
      内山貴誠、高田俊輔、敦賀英知、畠山雄次、石川博之、沢禎彦
    • Organizer
      第55回歯科基礎医学会学術大会・総会
    • Place of Presentation
      岡山
    • Related Report
      2013 Research-status Report
  • [Presentation] 糖尿病環境下の腎糸球体内皮細胞におけるTLR2とTLR4の発現2013

    • Author(s)
      高田俊輔、内山貴誠、敦賀英知、畠山雄次、石川博之、沢禎彦
    • Organizer
      第55回歯科基礎医学会学術大会・総会
    • Place of Presentation
      岡山
    • Related Report
      2013 Research-status Report
  • [Presentation] I型とII型糖尿病マウスにおける腎リンパ管増生について2013

    • Author(s)
      内山貴誠、高田俊輔、石川博之、沢禎彦
    • Organizer
      第51回日本糖尿病学会九州地方会
    • Place of Presentation
      沖縄
    • Related Report
      2013 Research-status Report
  • [Presentation] 糖尿病環境下の腎糸球体におけるToll-like receptor(TLR)2と4の発現2013

    • Author(s)
      高田俊輔、内山貴誠、石川博之、沢禎彦
    • Organizer
      第51回日本糖尿病学会九州地方会
    • Place of Presentation
      沖縄
    • Related Report
      2013 Research-status Report
  • [Presentation] I型とII型糖尿病モデルマウスにおける腎リンパ管新生について

    • Author(s)
      内山貴誠、高田俊輔、石川博之、沢禎彦
    • Organizer
      第40回福岡歯科大学学会総会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report
  • [Presentation] 糖尿病モデルマウスの腎糸球体におけるTLR2とTLR4の発現

    • Author(s)
      高田俊輔、内山貴誠、石川博之、沢禎彦
    • Organizer
      第40回福岡歯科大学学会総会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi